Do Omega-3/6 Fatty Acids Have a Therapeutic Role in Children and Young People with ADHD?

IF 5.9 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Lipids Pub Date : 2017-01-01 Epub Date: 2017-08-30 DOI:10.1155/2017/6285218

E Derbyshire

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引用次数: 25

Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is a debilitating behavioural disorder affecting daily ability to function, learn, and interact with peers. This publication assesses the role of omega-3/6 fatty acids in the treatment and management of ADHD.

Methods: A systematic review of 16 randomised controlled trials was undertaken. Trials included a total of 1,514 children and young people with ADHD who were allocated to take an omega-3/6 intervention, or a placebo.

Results: Of the studies identified, 13 reported favourable benefits on ADHD symptoms including improvements in hyperactivity, impulsivity, attention, visual learning, word reading, and working/short-term memory. Four studies used supplements containing a 9 : 3 : 1 ratio of eicosapentaenoic acid : docosahexaenoic acid : gamma linolenic acid which appeared effective at improving erythrocyte levels. Supplementation with this ratio of fatty acids also showed promise as an adjunctive therapy to traditional medications, lowering the dose and improving the compliance with medications such as methylphenidate.

Conclusion: ADHD is a frequent and debilitating childhood condition. Given disparaging feelings towards psychostimulant medications, omega-3/6 fatty acids offer great promise as a suitable adjunctive therapy for ADHD.

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Omega-3/6脂肪酸对儿童和青少年多动症有治疗作用吗?

背景:注意缺陷多动障碍(ADHD)是一种使人衰弱的行为障碍，影响日常功能、学习和与同伴互动的能力。本出版物评估了omega-3/6脂肪酸在ADHD治疗和管理中的作用。方法:对16项随机对照试验进行系统评价。试验共包括1514名患有多动症的儿童和青少年，他们被分配服用omega-3/6干预或安慰剂。结果:在已确定的研究中，13项报告了对ADHD症状的有利益处，包括多动症、冲动性、注意力、视觉学习、单词阅读和工作/短期记忆的改善。四项研究使用了含有9:3:1比例的二十碳五烯酸:二十二碳六烯酸:γ亚麻酸的补充剂，这似乎对改善红细胞水平有效。补充这种比例的脂肪酸也有望作为传统药物的辅助疗法，降低剂量并提高对哌醋甲酯等药物的依从性。结论:ADHD是一种常见的儿童期疾病。考虑到人们对精神兴奋剂药物的轻视，omega-3/6脂肪酸作为ADHD的一种合适的辅助疗法提供了很大的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Lipids BIOCHEMISTRY & MOLECULAR BIOLOGY-

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Journal of Lipids is a peer-reviewed, Open Access journal that publishes original research articles and review articles related to all aspects of lipids, including their biochemistry, synthesis, function in health and disease, and nutrition. As an interdisciplinary journal, Journal of Lipids aims to provide a forum for scientists, physicians, nutritionists, and other relevant health professionals.