The Role of Centromere Defects in Cancer.

Q2 Medicine

Progress in molecular and subcellular biology Pub Date : 2017-01-01 DOI:10.1007/978-3-319-58592-5_22

Thian Thian Beh, Paul Kalitsis

引用次数: 6

Abstract

The accurate segregation of chromosomes to daughter cells is essential for healthy development to occur. Imbalances in chromosome number have long been associated with cancers amongst other medical disorders. Little is known whether abnormal chromosome numbers are an early contributor to the cancer progression pathway. Centromere DNA and protein defects are known to impact on the fidelity of chromosome segregation in cell and model systems. In this chapter we discuss recent developments in understanding the contribution of centromere abnormalities at the protein and DNA level and their role in cancer in human and mouse systems.

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着丝粒缺陷在癌症中的作用。

染色体与子细胞的准确分离是健康发育的必要条件。长期以来，染色体数量的不平衡与癌症以及其他医学疾病有关。染色体数目异常是否为癌症进展途径的早期因素尚不清楚。着丝粒DNA和蛋白质的缺陷会影响细胞和模型系统中染色体分离的保真度。在本章中，我们讨论了在蛋白质和DNA水平上理解着丝粒异常的贡献及其在人类和小鼠系统中癌症中的作用的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in molecular and subcellular biology Medicine-Medicine (all)

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Molecular biology has been providing an overwhelming amount of data on the structural components and molecular machineries of the cell and its organelles and the complexity of intra- and intercellular communication. The molecular basis of hereditary and acquired diseases is beginning to be unravelled, and profound new insights into development and evolutionary biology have been gained from molecular approaches. Progress in Molecular and Subcellular Biology summarises the most recent developments in this fascinating area of biology.