Functional Decline is Associated with Hopelessness in Amyotrophic Lateral Sclerosis (ALS).

Journal of neurology & neurophysiology Pub Date : 2017-04-01 Epub Date: 2017-04-29 DOI:10.4172/2155-9562.1000423

Sabrina Paganoni, Erin McDonnell, David Schoenfeld, Hong Yu, Jing Deng, Hamza Atassi, Alexander Sherman, Padmaja Yerramilli-Rao, Merit Cudkowicz, Nazem Atassi

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引用次数: 16

Abstract

Objective: To determine the relationships between hopelessness, depression, quality of life, and disease progression in ALS.

Methods: Hopelessness and depression were assessed prospectively in a cohort of people with ALS using the Beck Hopelessness scale (BHS) and the ALS Depression Inventory (ADI-12), respectively. ALS Specific Quality of Life and measures of functional status (ALSFRS-R and forced vital capacity) were collected. Associations between changes in psychological health and functional scores were calculated using Spearman correlation coefficients.

Results: Twenty-five people with ALS had at least 2 visits and were followed for a mean of 11 (± 6) months. People with hopelessness and depression reported worse quality of life (p<0.01 for both associations). Decline in function between any two visits measured by ALSFRS-R (p<0.01) and FVC (p=0.02) correlated with increased hopelessness, but not depression.

Conclusion: This study highlights the importance of monitoring hopelessness in ALS, particularly in patients with faster functional decline.

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肌萎缩性侧索硬化症(ALS)的功能衰退与绝望有关。

目的:探讨ALS患者绝望、抑郁、生活质量和疾病进展之间的关系。方法:采用贝克绝望量表(BHS)和ALS抑郁量表(ADI-12)对一组ALS患者的绝望和抑郁进行前瞻性评估。收集ALS特异性生活质量和功能状态指标(ALSFRS-R和用力肺活量)。使用Spearman相关系数计算心理健康变化与功能评分之间的关联。结果:25例ALS患者至少有2次就诊，平均随访11(±6)个月。结论:本研究强调了监测ALS患者的绝望情绪的重要性，特别是在功能衰退更快的患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of neurology & neurophysiology

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