The Role of the Calcitonin Peptide Family in Prostate Cancer and Bone Metastasis.

Current molecular biology reports Pub Date : 2017-01-01 Epub Date: 2017-08-02 DOI:10.1007/s40610-017-0071-9

Jessica Isabel Warrington, Gareth Owain Richards, Ning Wang

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引用次数: 14

Abstract

Purpose of review: This study is to highlight recent discoveries associated with the role of calcitonin peptide family and their receptors in prostate cancer progression and bone metastasis.

Recent findings: Studies have linked adrenomedullin (AM), calcitonin (CT) and calcitonin gene-related peptide (CGRP) to the spread of prostate tumours to the bone. AM can induce a metastatic phenotype in prostate cancer cells through its action on TRPV2 calcium channels and is also capable of influencing localised levels of RANKL in the bone to favour tumourigenesis. CT utilises A-kinase anchoring proteins to indirectly act on PKA and promote metastasis in prostate cancer. The receptor for CT contains a PDZ-binding domain, the deletion of which stops metastasis to the bone in orthotopic prostate models.

Summary: Recent findings show strong evidence for the role of calcitonin peptides and receptors in prostate cancer and bone metastasis. Further research could provide potential prognostic markers and therapeutic targets for prostate cancer patients.

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降钙素肽家族在前列腺癌和骨转移中的作用。

综述目的:本研究旨在综述降钙素肽家族及其受体在前列腺癌进展和骨转移中的作用。最近的发现:研究表明肾上腺髓质素(AM)、降钙素(CT)和降钙素基因相关肽(CGRP)与前列腺肿瘤向骨骼的扩散有关。AM可以通过其对TRPV2钙通道的作用在前列腺癌细胞中诱导转移表型，并且还能够影响骨中RANKL的局部水平以促进肿瘤的发生。CT利用a激酶锚定蛋白间接作用于PKA，促进前列腺癌转移。CT受体含有pdz结合结构域，在原位前列腺模型中，该结构域的缺失可以阻止转移到骨。摘要:最近的研究结果有力地证明了降钙素肽和受体在前列腺癌和骨转移中的作用。进一步的研究可以为前列腺癌患者提供潜在的预后标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current molecular biology reports

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