Mirzafaraz Saeed, Hari Hullur, Amro Salem, Abbas Ali, Yousif Sahib, Mobeen Ashfaq
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引用次数: 2
Abstract
Introduction: The aim of this study is to evaluate the outcome of introduction of early surgery in the course of isolated ileocecal Crohn's disease, where there is no absolute indication of surgery.
Methods: Observational study involving patients with isolated ileocecal Crohn's disease who underwent early surgical resection (within one year of the presentation of the hospital). A complete blood count, ESR, and CRP were done and compared between the preoperative value, 1st postoperative visit (3-4 weeks), and last follow-up visit. Statistical analysis was done using Analysis of Variance (ANOVA) to compare the different figures.
Results: There was a statistically significant increase in the hemoglobin levels between preoperative, postoperative, and long-term follow-up and a significant decrease in leukocyte count between the pre- and postoperative values (F = 19.8, p < 0.001 and F = 8.9, p = 0.002, resp.). Similarly, the ESR and CRP values were decreased significantly at long-term follow-up (F = 8.5, p = 0.019 and F = 8.3, p = 0.013, resp.).
Conclusion: Early surgical resection in isolated ileocaecal Crohn's disease achieved significant biochemical improvements. These successful results in this small number of patients indicate that early surgical intervention may provide better outcomes. These initial results encourage larger and comparative studies of long-term results versus long-term use of biological agents.
本研究的目的是评估在孤立回盲部克罗恩病过程中引入早期手术的结果,其中没有绝对的手术指征。方法:观察性研究纳入了早期手术切除的孤立回盲部克罗恩病患者(入院一年内)。进行全血细胞计数、ESR和CRP,并比较术前值、术后第一次随访(3-4周)和最后一次随访。采用方差分析(ANOVA)进行统计分析,比较不同数据。结果:术前、术后及长期随访血红蛋白水平均有统计学意义升高,白细胞计数与术前、术后比较均有统计学意义降低(F = 19.8, p < 0.001; F = 8.9, p = 0.002,均有统计学意义)。同样,在长期随访中,ESR和CRP值也显著降低(F = 8.5, p = 0.019和F = 8.3, p = 0.013,均有统计学意义)。结论:早期手术切除孤立回肠盲区克罗恩病可显著改善其生化指标。这些在少数患者中的成功结果表明,早期手术干预可能会提供更好的结果。这些初步结果鼓励对长期效果与长期使用生物制剂进行更大规模的比较研究。
期刊介绍:
Surgery Research and Practice is a peer-reviewed, Open Access journal that provides a forum for surgeons and the surgical research community. The journal publishes original research articles, review articles, and clinical studies focusing on clinical and laboratory research relevant to surgical practice and teaching, with an emphasis on findings directly affecting surgical management.