Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.
Neil G Burnet, Jessica E Scaife, Marina Romanchikova, Simon J Thomas, Amy M Bates, Emma Wong, David J Noble, Leila Ea Shelley, Simon J Bond, Julia R Forman, Andrew Cf Hoole, Gillian C Barnett, Frederic M Brochu, Michael Pd Simmons, Raj Jena, Karl Harrison, Ping Lin Yeap, Amelia Drew, Emma Silvester, Patrick Elwood, Hannah Pullen, Andrew Sultana, Shannon Yk Seah, Megan Z Wilson, Simon G Russell, Richard J Benson, Yvonne L Rimmer, Sarah J Jefferies, Nicolette Taku, Mark Gurnell, Andrew S Powlson, Carola-Bibiane Schönlieb, Xiaohao Cai, Michael Pf Sutcliffe, Michael A Parker
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引用次数: 17
Abstract
The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.
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