Inflammation and Colorectal Cancer.

Q3 Medicine

Current Colorectal Cancer Reports Pub Date : 2017-08-01 Epub Date: 2017-06-17 DOI:10.1007/s11888-017-0373-6

Apple G Long, Emma T Lundsmith, Kathryn E Hamilton

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Abstract

Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critical hallmark of cancer that may arise from a variety of factors.

Purpose of review: While patients with inflammatory bowel disease (IBD) have a higher risk of developing CRC, sporadic CRCs may engender or be potentiated by inflammation as well. In this review, we focus on recent advances in basic and translational research utilizing murine models to understand the contribution of inflammatory signaling pathways to CRC.

Recent findings: We discuss advances in the utility of three-dimensional enteroid/colonoid/tumoroid cultures to understand immune-epithelial interactions in CRC, as well as the potential for utilizing patient-derived tumoroids for personalized therapies.

Summary: This review underscores the importance of understanding the complex molecular mechanisms underlying inflammation in sporadic CRC and highlights up-and-coming or new avenues for CRC biomarkers or therapies.

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炎症与结直肠癌。

结肠直肠癌（CRC）是美国男性和女性第四大常见癌症，每年导致 55,000 多人死亡。环境和遗传因素影响着 CRC 的发展，而炎症是癌症的一个重要标志，可能由多种因素引起：尽管炎症性肠病（IBD）患者罹患 CRC 的风险较高，但散发性 CRC 也可能因炎症而产生或加剧。在这篇综述中，我们将重点介绍基础研究和转化研究的最新进展，利用小鼠模型来了解炎症信号通路对 CRC 的影响：摘要：本综述强调了了解散发性 CRC 炎症的复杂分子机制的重要性，并重点介绍了 CRC 生物标记物或疗法的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Colorectal Cancer Reports ONCOLOGY-

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期刊介绍： This journal aims to review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of colorectal cancer. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those with the disease. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and emerging therapeutic approaches and the molecular basis of disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.