Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats.

Journal of Evidence-Based Complementary & Alternative Medicine Pub Date : 2017-10-01 Epub Date: 2017-02-21 DOI:10.1177/2156587217692491

Saeed Samarghandian, Abasalt Borji, Tahereh Farkhondeh

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Abstract

The present study was designed to investigate the protective effect of the aqueous extract of Portulaca oleracea against hyperglycemic, oxidative damage and inflammation in the serum of streptozotocin (STZ)-induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 Portulaca oleracea (100, 200, 400 mg/kg/d)-treated diabetic groups. At the end of the 4-week period, glucose, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), glutathione (GSH), and total antioxidant status (TAS) levels were measured. STZ caused an elevation in the serum levels of glucose, MDA, IL-6, and TNF-α with reduction in the levels of GSH and TAS ( P < .01). Portulaca oleracea ameliorated glucose, MDA, IL-6, TNF-α, GSH, and TAS levels in diabetic groups versus to the untreated groups ( P < .05). Taken together, Portulaca oleracea prevented hyperglycemia by preventing the oxidative stress and inflammation.

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马齿苋对链脲佐菌素诱导的糖尿病大鼠氧化应激和炎症的抑制作用

本研究旨在探讨马齿苋水提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠血清中高血糖、氧化损伤和炎症的保护作用。在本研究中，大鼠被分为以下几组，每组 8 只：对照组、未治疗糖尿病组和 3 个马齿苋（100、200、400 mg/kg/d）治疗糖尿病组。在为期 4 周的研究结束时，测量血糖、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）、谷胱甘肽（GSH）和总抗氧化状态（TAS）的水平。STZ导致血清中葡萄糖、MDA、IL-6和TNF-α水平升高，GSH和TAS水平降低（P < .01）。与未治疗组相比，马齿苋可改善糖尿病组的血糖、MDA、IL-6、TNF-α、GSH 和 TAS 水平 ( P < .05)。综上所述，马齿苋通过防止氧化应激和炎症来预防高血糖。

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来源期刊

Journal of Evidence-Based Complementary & Alternative Medicine

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： The Journal of Evidence-Based Integrative Medicine ((JEBIM)), published previously as the Journal of Evidence-Based Complementary and Alternative Medicine (JEBCAM) and also as Complementary Health Practice Review (CHPR). The Journal of Evidence-Based Integrative Medicine (JEBIM) is an interdisciplinary, peer-reviewed, open access, biomedical journal whose aim is to create a global platform for hypothesis-driven and evidence-based research in all fields of integrative medicine. The journal’s objective is to publish papers which impart scientific validity to Integrative Medicine methods that are indispensable and inevitable in today’s world. All papers will be peer reviewed by experts in their respective fields, and papers will be accepted based on their scientific merit. It is the goal of the Journal to help remove the “myth” and provide scientific rationale for the various methodologies and theories of Integrative Medicine. All submissions will be reviewed based on their scientific merit and only papers with sound study design, valid statistical analyses and logical conclusions will be accepted. Topics include, but are not limited to: Traditional Eastern and Western medicine Nutrition therapy and supplementation Massage Therapy Non-traditional treatments Preventative medicine Integrative health and medicine Mindfulness Yoga.