LATENT TUBERCULOSIS AMONG ADULT ETHIOPIAN PATIENTS AT CHEST CLINIC, TIKURANBESSA SPECIALIZED HOSPITAL, ADDIS ABABA, ETHIOPIA.

Q3 Medicine

Ethiopian Medical Journal Pub Date : 2016-10-01

Amsalu Bekele, Senait Ashenafi, Getachew Aderay, Getachew Assefa, Abraham Aseffa, Jan Anderssen, Susanna Brighenti

{"title":"LATENT TUBERCULOSIS AMONG ADULT ETHIOPIAN PATIENTS\nAT CHEST CLINIC, TIKURANBESSA SPECIALIZED HOSPITAL,\nADDIS ABABA, ETHIOPIA.","authors":"Amsalu Bekele, Senait Ashenafi, Getachew Aderay, Getachew Assefa, Abraham Aseffa, Jan Anderssen, Susanna Brighenti","doi":"","DOIUrl":null,"url":null,"abstract":"Background: One-third of the world population is infected with Mycobacterium tuberculosis. Most people exposed\nto M. tuberculosis showed no evidence of active disease. About 5-10% of people with latent tuberculosis infection\n(LTBI) without HIV will progress to develop active tuberculosis (TB) in their lifetimes. This study was conducted to\ndetermine the magnitude of latent TB among the adult population at a teaching and referral Hospital in Ethiopia.Methods: This study was conducted at the Chest clinic of Tikur Anbessa Specialized Hospital during 2010-2013.\nThe study was a cross-sectional study conducted among healthy adults after informed consent was obtained from\neach individual. Tuberculin skin test (TST) and Interferon Gamma whole blood assay (Quantiferon-Tuberculosis-\nGold) was performed using enzyme linked immuno-sorbent assay. Average CD4, CD8, CD3 and CD4:CD8 ratio\nwas determined for all study participants.Results: From a total of 70 healthy adults tested for LTBI using Quantiferon Gold, 45(64%) tested positive and 25\n(36%) were negative for latent tuberculosis infection. From the 66 healthy individuals who were tested using TST\nfor LTBI, 42 (62%) individuals were TST positive and 25 (38%) individuals were TST negative. Average CD4,\nCD8, CD3 and CD4:CD8 ratio was 748, 598, 1401 and 1.4, respectively.Conclusions: The magnitude of latent tuberculosis infection was high in this study, which reflects existing high\nprevalence of TB. TST and Quantiferon-Tuberculosis-Gold assay show similar efficacy for the diagnosis of LTBI in\nhealthy Ethiopian adults. The absolute CD4 T-cell counts of healthy HIV- negative Ethiopians are considerably\nlower than CD4 T cell counts in other countries.","PeriodicalId":11937,"journal":{"name":"Ethiopian Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ethiopian Medical Journal","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: One-third of the world population is infected with Mycobacterium tuberculosis. Most people exposed to M. tuberculosis showed no evidence of active disease. About 5-10% of people with latent tuberculosis infection (LTBI) without HIV will progress to develop active tuberculosis (TB) in their lifetimes. This study was conducted to determine the magnitude of latent TB among the adult population at a teaching and referral Hospital in Ethiopia.

Methods: This study was conducted at the Chest clinic of Tikur Anbessa Specialized Hospital during 2010-2013. The study was a cross-sectional study conducted among healthy adults after informed consent was obtained from each individual. Tuberculin skin test (TST) and Interferon Gamma whole blood assay (Quantiferon-Tuberculosis- Gold) was performed using enzyme linked immuno-sorbent assay. Average CD4, CD8, CD3 and CD4:CD8 ratio was determined for all study participants.

Results: From a total of 70 healthy adults tested for LTBI using Quantiferon Gold, 45(64%) tested positive and 25 (36%) were negative for latent tuberculosis infection. From the 66 healthy individuals who were tested using TST for LTBI, 42 (62%) individuals were TST positive and 25 (38%) individuals were TST negative. Average CD4, CD8, CD3 and CD4:CD8 ratio was 748, 598, 1401 and 1.4, respectively.

Conclusions: The magnitude of latent tuberculosis infection was high in this study, which reflects existing high prevalence of TB. TST and Quantiferon-Tuberculosis-Gold assay show similar efficacy for the diagnosis of LTBI in healthy Ethiopian adults. The absolute CD4 T-cell counts of healthy HIV- negative Ethiopians are considerably lower than CD4 T cell counts in other countries.

本刊更多论文

埃塞俄比亚亚的斯亚贝巴tikuranbessa专科医院胸科门诊，埃塞俄比亚成年患者的潜伏性肺结核。

背景:世界上三分之一的人口感染了结核分枝杆菌。大多数暴露于结核分枝杆菌的人没有表现出活动性疾病的迹象。大约5-10%的未感染艾滋病毒的潜伏性结核感染(LTBI)患者将在其一生中发展为活动性结核病(TB)。本研究是在埃塞俄比亚的一家教学和转诊医院进行的，目的是确定成人人群中潜伏性结核病的程度。方法:本研究于2010-2013年在提库尔安贝萨专科医院胸科门诊进行。该研究是一项横断面研究，在获得每个个体的知情同意后，在健康成年人中进行。采用酶联免疫吸附法进行结核菌素皮肤试验(TST)和干扰素γ全血试验(Quantiferon-Tuberculosis-Gold)。测定所有研究参与者的平均CD4、CD8、CD3和CD4:CD8比值。结果:在总共70名健康成人中，使用Quantiferon Gold进行LTBI检测，45名(64%)检测阳性，25名(36%)检测阴性。在66名健康的LTBI患者中，42人(62%)TST阳性，25人(38%)TST阴性。平均CD4、CD8、CD3和CD4:CD8比值分别为748、598、1401和1.4。结论:本研究中潜伏性结核感染的程度较高，反映了结核病的高患病率。TST和Quantiferon-Tuberculosis-Gold试验对埃塞俄比亚健康成人LTBI的诊断效果相似。健康的HIV阴性埃塞俄比亚人的CD4 T细胞绝对计数明显低于其他国家的CD4 T细胞计数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ethiopian Medical Journal Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： The Ethiopian Medical Journal (EMJ) is the official Journal of the Ethiopian Medical Association (EMA) and devoted to the advancement and dissemination of knowledge pertaining to the broad field of medicine in Ethiopia and other developing countries. Prospective contributors to the Journal should take note of the instructions of Manuscript preparation and submission to EMJ as outlined below.