A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees.

U.S. Army Medical Department journal Pub Date : 2017-10-01

David J Tennent, Christina M Hylden, Benjamin K Kocher, James K Aden, Anthony E Johnson

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Abstract

Background: Methylsulfonylmethane (MSM) is a naturally occurring sulfur containing substance that has been shown to have anti-inflammatory and antioxidative properties. Previous studies using MSM as an oral supplement to improve pain in those patients with knee osteoarthritis have shown superiority compared to placebo. However, these studies are not translatable to active individuals performing high impact activities and have not evaluated MSM as a preventative measure.

Methods: A total of 180 subjects ranging in age from 18 to 40 years were enrolled. Subjects were randomized into 2 groups receiving either 3 grams OptiMSM methylsulfonylmethane (Bergstrom Nutrition, Vancouver, WA) or a placebo for 8 weeks. Outcomes measured were the Knee Osteoarthritis Outcome Score (KOOS) and the Profile of Moods States (POMS).

Results: Three grams of MSM administered daily did not provide significant improvements in the 5 KOOS subscales or the 6 POMS subscales at 30 days or 60 days.

Conslusion: Although 3 grams of MSM daily can be used safely, there does not appear to be a significant improvement in KOOS or POMS.

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一项随机对照试验评估甲基磺酰甲烷与安慰剂预防军事初入受训人员膝关节疼痛。

背景:甲基磺酰甲烷(MSM)是一种天然存在的含硫物质，已被证明具有抗炎和抗氧化特性。先前的研究使用MSM作为口服补充剂来改善膝骨关节炎患者的疼痛，与安慰剂相比显示出优越性。然而，这些研究并不适用于从事高影响活动的活跃个人，也没有评估男男性行为作为预防措施。方法:共入组180例受试者，年龄18 ~ 40岁。受试者被随机分为两组，接受3克OptiMSM甲基磺酰甲烷(Bergstrom Nutrition, Vancouver, WA)或安慰剂治疗，为期8周。测量的结果是膝关节骨关节炎结局评分(oos)和情绪状态概况(POMS)。结果:在30天或60天，每天服用3克MSM对5个oos亚量表或6个POMS亚量表没有显著改善。结论:虽然每天服用3克MSM是安全的，但在kos或POMS方面并没有明显的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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U.S. Army Medical Department journal

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