The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases.

Current molecular biology reports Pub Date : 2017-01-01 Epub Date: 2017-10-23 DOI:10.1007/s40610-017-0076-4

Emma Budd, Shona Waddell, María C de Andrés, Richard O C Oreffo

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引用次数: 12

Abstract

Purpose of review: Degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset.

Recent findings: The combination of stem cells and miRNA has been successful at regenerating the bone and cartilage in vivo. MiRNAs, including miR-146b known to be involved in chondrogenic differentiation, could provide innovative targets for stem cell-based therapy, for the repair of articular cartilage defects forestalling the onset of OA or in the generation of a stem cell-based therapy for OP.

Summary: This review discusses the combination of skeletal stem cells (SSCs) and candidate miRNAs for application in a cell-based therapy approach for skeletal regenerative medicine.

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microrna在退行性骨骼疾病干细胞治疗中的潜力

综述目的:退行性骨骼疾病包括骨关节炎(OA)和骨质疏松症(OP)是组织再生衰减的结果，导致疼痛，治疗选择有限。预防措施，以限制发作的OA和OP仍然是一个重要的未满足的临床需求。已知MicroRNAs (miRNAs)参与干细胞的分化，并与干细胞治疗联合可诱导骨骼再生，并可能预防OA和OP的发病。最近的研究发现:干细胞和miRNA的结合已经成功地在体内再生骨和软骨。mirna，包括已知参与软骨分化的miR-146b，可以为干细胞治疗提供创新靶点，用于修复关节软骨缺陷，预防OA发作，或用于生成基于OA的干细胞治疗方法。摘要:本文讨论了骨骼干细胞(ssc)和候选mirna的组合，用于骨骼再生医学的细胞治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current molecular biology reports

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