Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis.

IF 2.3 Q2 RHEUMATOLOGY
International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-10-29 DOI:10.1155/2017/4029584
C Romero-Sánchez, W Bautista-Molano, V Parra, J De Avila, J C Rueda, J M Bello-Gualtero, J Londoño, R Valle-Oñate
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引用次数: 10

Abstract

Background: Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status.

Objectives: To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD).

Methods: 102 SpA patients, 29 IBD patients, and 117 HS were included. Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured. The patients were assessed to evaluate clinical and gastrointestinal symptoms. An association analysis was performed using Chi square test and a logistic regression.

Results: Significant differences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) (p = 0.029), as well as for ANAS in SpA (49.5%) and IBD (37.9%) (p < 0.001) and abdominal pain (p = 0.012) between SpA (54.3%) and IBD (27.5%). Significant associations were found between BASDAI > 4 and gastrointestinal symptoms (p < 0.05) and IgA (p = 0.007). The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14-13.56; p = 0.030).

Conclusions: Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS.

Abstract Image

哥伦比亚脊椎关节炎患者的胃肠道症状和抗酿酒酵母抗体水平升高与较高的疾病活动性相关
背景:脊椎关节炎(Spondyloarthritis, SpA)是一类关节炎性风湿病,其胃肠道表现约占关节外症状的10%,支持肠黏膜炎症反应可能与临床状态相关。目的:探讨SpA患者、健康人(HS)和炎症性肠病(IBD)患者胃肠道症状、自身抗体和疾病活动性之间的关系。方法:选取SpA患者102例,IBD患者29例,HS患者117例。检测自身抗体ASCA、ANCA、抗ttg、抗dgp、ANA、IgA。对患者进行临床和胃肠道症状评估。采用卡方检验和逻辑回归进行关联分析。结果:SpA患者ASCA水平(28.2%)与IBD患者(14.2%)和HS患者(6.0%)相比(p = 0.029), SpA患者ANAS水平(49.5%)与IBD患者(37.9%)(p < 0.001),腹痛水平(p = 0.012)在SpA患者(54.3%)与IBD患者(27.5%)之间存在显著差异。BASDAI > 4与胃肠道症状(p < 0.05)和IgA (p = 0.007)有显著相关性。与腹胀的相关性保持不变(OR: 3.93, CI-95%, 1.14-13.56;P = 0.030)。结论:与IBD和HS相比,SpA患者的胃肠道症状、ASCA、ANAS和IgA水平与高疾病活动性相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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