A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia.

Q2 Medicine

BMC Hematology Pub Date : 2017-11-28 eCollection Date: 2017-01-01 DOI:10.1186/s12878-017-0093-9

Bamlaku Enawgaw, Nigist Adane, Betelihem Terefe, Fikir Asrie, Mulugeta Melku

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引用次数: 22

Abstract

Background: Hypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological parameters may enhance an end-organ damage. Therefore, the aim of this study was to assess some hematological parameters of hypertensive individuals in comparison with normotensive individuals at University of Gondar hospital, northwest Ethiopia.

Methods: A cross sectional comparative study was conducted from October to November 2015 on a total of 126 hypertensive and 126 normotensive individuals at University of Gondar Hospital. All participants after taking informed consent were interviewed for detailed history and 3 ml of blood was collected for hematological test analysis. Independent t-test and the Mann Whitney u-test were used to find out significant difference and Pearson's and Spearman's correlation were used for correlation test. P values less than 0.05 was considered the level of significance.

Result: From a total of 252 study subjects, about 67.5% were females. The mean age of study subjects was 50.3 ± 11 years for hypertensive individuals and 49.8 ± 11.6 years for normotensive individuals with range of 18-65 years. In the present study, the median (IQR) value of WBC, RBC, Hgb, HCT, MCV and the mean value of MCHC, RDW, MPV and PDW were significantly higher in hypertensive group compared to apparently healthy normotensive groups. Additionally, WBC, RBC, Hgb, HCT and PLT showed statistically significant positive correlations with blood pressure indices. Platelet count and MCH did not show statistically significant difference between the two groups.

Conclusion: Hypertension has impact on hematological parameters. In this study, the mean and median values of haematological parameters in hypertensive individuals were significantly different compared to apparently healthy normotensive individuals. Hence, hematological parameters can be used to monitor the prognosis of the disease and manage hypertensive related complications, and it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated hematological disorders.

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埃塞俄比亚西北部Gondar大学医院高血压和正常个体的一些血液学参数的比较横断面研究。

背景:高血压是世界范围内的主要健康问题。它会导致心血管疾病，也会导致包括血液学参数在内的功能障碍。血液学参数异常可加重终末器官损伤。因此，本研究的目的是评估埃塞俄比亚西北部贡达尔大学医院高血压患者与正常患者的一些血液学参数。方法:2015年10 - 11月对贡达尔大学医院126例高血压患者和126例正常患者进行横断面对比研究。在知情同意后，对所有参与者进行详细的病史访谈，并采集3ml血液进行血液学检测分析。采用独立t检验和Mann Whitney u检验发现显著性差异，采用Pearson’s和Spearman’s相关进行相关性检验。P值小于0.05为显著性水平。结果:252名研究对象中，女性约占67.5%。高血压患者的平均年龄为50.3±11岁，正常患者的平均年龄为49.8±11.6岁，年龄范围为18-65岁。在本研究中，高血压组的WBC、RBC、Hgb、HCT、MCV的中位数(IQR)值以及MCHC、RDW、MPV、PDW的平均值均明显高于表面健康的正常血压组。WBC、RBC、Hgb、HCT、PLT与血压指标呈显著正相关。两组患者血小板计数、MCH差异无统计学意义。结论:高血压对血液学指标有影响。在这项研究中，高血压个体的血液学参数的平均值和中位数与表面健康的正常个体相比有显著差异。因此，血液学参数可用于监测疾病的预后和控制高血压相关并发症，对高血压患者进行血液学参数评估可能有助于预防与血液学疾病相关的并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Hematology Medicine-Hematology

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.