Paracoccidioidomycosis: Current Perspectives from Brazil.

Q3 Immunology and Microbiology

Open Microbiology Journal Pub Date : 2017-10-31 eCollection Date: 2017-01-01 DOI:10.2174/1874285801711010224

Rinaldo Poncio Mendes, Ricardo de Souza Cavalcante, Sílvio Alencar Marques, Mariângela Esther Alencar Marques, James Venturini, Tatiane Fernanda Sylvestre, Anamaria Mello Miranda Paniago, Ana Carla Pereira, Julhiany de Fátima da Silva, Alexandre Todorovic Fabro, Sandra de Moraes Gimenes Bosco, Eduardo Bagagli, Rosane Christine Hahn, Adriele Dandara Levorato

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引用次数: 103

Abstract

Background: This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.

Objectives: Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings.

Methods: Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.

Results: Clinical forms have been better classified in order to include the pictures less frequently observesiod.

Conclusion: Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.

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副球虫病：来自巴西的最新观点。

背景：这篇综述文章总结和更新了对副球虫病的认识。卢齐氏毕赤酵母和巴西毕赤酵母的隐种及其在拉丁美洲的地理分布，解释了血清学诊断中观察到的困难。目的：强调一些遗传因素作为副球虫病的易感条件。重点关注兽医方面，显示感染在动物中的广泛分布。结合最近的发现，细胞介导的免疫得到了更好的表征。方法：还比较了血清学诊断方法的准确性参数，包括复发分析。结果：临床形式得到了更好的分类，以便包括观察频率较低的图片。结论：比较了伊曲康唑与甲氧苄啶-磺胺甲恶唑联合用药的疗效、有效性和安全性，表明唑类药物应是治疗副球虫病的首选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Microbiology Journal Immunology and Microbiology-Immunology and Microbiology (all)

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Open Microbiology Journal is a peer-reviewed open access journal which publishes research articles, reviews/mini-reviews, case studies, guest edited thematic issues and short communications/letters covering theoretical and practical aspects of Microbial systematics, evolutionary microbiology, immunology, virology, parasitology , bacteriology, mycology, phycology, protozoology, microbial ecology, molecular biology, microbial physiology, biochemistry, microbial pathogenesis, host-microbe interaction, systems microbiology, synthetic microbiology, bioinformatics. The Open Microbiology Journal , a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and freely available to researchers worldwide.