Recommendations of the Brazilian Society of Rheumatology for the diagnosis and treatment of chikungunya fever. Part 2 – Treatment

Revista Brasileira de Reumatologia (English Edition) Pub Date : 2017-01-01 DOI:10.1016/j.rbre.2017.06.004

Claudia Diniz Lopes Marques , Angela Luzia Branco Pinto Duarte , Aline Ranzolin , Andrea Tavares Dantas , Nara Gualberto Cavalcanti , Rafaela Silva Guimarães Gonçalves , Laurindo Ferreira da Rocha Junior , Lilian David de Azevedo Valadares , Ana Karla Guedes de Melo , Eutilia Andrade Medeiros Freire , Roberto Teixeira , Francisco Alves Bezerra Neto , Marta Maria das Chagas Medeiros , Jozélio Freire de Carvalho , Mario Sergio F. Santos , Regina Adalva de L. Couto Océa , Roger A. Levy , Carlos Augusto Ferreira de Andrade , Geraldo da Rocha Castelar Pinheiro , Mirhelen Mendes Abreu , Georges Christopoulos

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引用次数: 24

Abstract

Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. There are a few studies on the treatment of musculoskeletal manifestations of chikungunya fever, but these studies have important methodological limitations. The data currently available preclude conclusions favorable or contrary to specific therapies, or an adequate comparison between the different drugs used.

The objective of this study was to develop recommendations for the treatment of chikungunya fever in Brazil. A literature review was performed via evidence-based selection of articles in the databases Medline, SciELO, PubMed and Embase and conference proceedings abstracts, in addition to expert opinions to support decision-making in defining recommendations. The Delphi method was used to define the degrees of agreement in 2 face-to-face meetings and several online voting rounds. This study is part 2 of the Recommendations of the Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia – SBR) for the Diagnosis and Treatment of chikungunya fever and specifically addresses treatment.

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巴西风湿病学会关于基孔肯雅热诊断和治疗的建议。第2部-处理

基孔肯雅热在发生流行病的国家已成为一个重要的公共卫生问题，因为半数病例发展为慢性、持续性和使人衰弱的关节炎。关于基孔肯雅病毒(CHIKV)感染引起的关节病不同阶段特异性治疗的文献资料有限，缺乏评估不同治疗效果的高质量随机试验。有一些关于治疗基孔肯雅热肌肉骨骼表现的研究，但这些研究在方法学上有重要的局限性。目前可获得的数据排除了支持或反对特定治疗的结论，或不同药物之间的充分比较。这项研究的目的是为巴西基孔肯雅热的治疗提出建议。文献综述是通过基于证据的选择Medline、SciELO、PubMed和Embase数据库中的文章和会议论文集摘要，以及专家意见来支持确定建议的决策。采用德尔菲法确定了2次面对面会议和几轮在线投票的一致程度。这项研究是巴西风湿病学会(Sociedade Brasileira de Reumatologia - SBR)关于基孔肯雅热诊断和治疗建议的第二部分，具体涉及治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista Brasileira de Reumatologia (English Edition)

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