Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2017-07-17 eCollection Date: 2018-01-01 DOI:10.1186/s41065-017-0037-1

Wei Xu, Yahui Liu, Jianhua Chen, Qingli Guo, Ke Liu, Zujia Wen, Zhaowei Zhou, Zhijian Song, Juan Zhou, Lin He, Qizhong Yi, Yongyong Shi

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引用次数: 11

Abstract

Background: Schizophrenia (SCZ) is a common mental disorder with high heritability, and genetic factors play a major role in the pathogenesis. Recent researches indicated that the CACNA1I involved in calcium channels probably affect the potential pathogenesis of SCZ.

Results: In this study, we attempted to investigate whether the CACNA1I gene contributes the risk to SCZ in the Uighur Chinese population, and performed a case-control study involving 985 patient samples and 1218 normal controls to analyze nine SNPs within the CACNA1I gene. Among these sites, six SNPs were significantly associated with SCZ in the allele distribution: rs132575 (adjusted P_allele = 0.039, OR = 1.159), rs713860 (adjusted P_allele = 0.039, OR = 0.792), rs738168 (adjusted P_allele = 0.039, OR = 0.785), rs136805 (adjusted P_allele = 0.014, OR = 1.212), rs5757760 (adjusted P_allele = 0.042, OR = 0.873) and rs5750871 (adjusted P_allele = 0.039, OR = 0.859). In addition, two SNPs turned to be risk factors for SCZ not only in the allele distribution, but also in the genotype distribution: rs132575 (adjusted P_genotype = 0.037) and rs136805 (adjusted P_genotype = 0.037).

Conclusions: Overall, the present study provided evidence that significant association exists between the CACNA1I gene and SCZ in the Uighur Chinese population, subsequent validation of functional analysis and genetic association studies are needed to further extend this study.

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中国维吾尔族人群中CACNA1I基因与精神分裂症的遗传风险

背景:精神分裂症(SCZ)是一种常见的高遗传性精神障碍，遗传因素在其发病机制中起重要作用。最近的研究表明，CACNA1I参与钙通道可能影响SCZ的潜在发病机制。结果:在本研究中，我们试图探讨CACNA1I基因是否与维吾尔族人群的SCZ风险有关，并进行了一项涉及985例患者样本和1218例正常对照的病例对照研究，分析了CACNA1I基因内的9个snp。在这些位点中，有6个snp在等位基因分布上与SCZ显著相关:rs132575(调整后的Pallele = 0.039, OR = 1.159)、rs713860(调整后的Pallele = 0.039, OR = 0.792)、rs738168(调整后的Pallele = 0.039, OR = 0.785)、rs136805(调整后的Pallele = 0.014, OR = 1.212)、rss5757760(调整后的Pallele = 0.042, OR = 0.873)和rss5750871(调整后的Pallele = 0.039, OR = 0.859)。另外，rs132575(校正Pgenotype = 0.037)和rs136805(校正Pgenotype = 0.037)这两个snp不仅在等位基因分布上，而且在基因型分布上都成为SCZ的危险因素。结论:总体而言，本研究提供的证据表明，在维吾尔族人群中，CACNA1I基因与SCZ存在显著关联，需要后续的功能分析验证和遗传关联研究来进一步扩展本研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464