Effect of Repetitive Transcranial Magnetic Stimulation on Cigarette Smoking in Patients with Schizophrenia.

上海精神医学 Pub Date : 2016-12-25 DOI:10.11919/j.issn.1002-0829.216044

Wanli Huang, Fang Shen, Jiangtao Zhang, Baoping Xing

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引用次数: 20

Abstract

Background: The high smoking rate among patients with schizophrenia is an important public health problem, and researchers have been studying how to change the status quo.

Objective: We investigated the effects of high frequency (10Hz) repetitive transcranial magnetic stimulation on the amount of cigarette smoking in patients with schizophrenia.

Method: This study enrolled 37 male patients with schizophrenia who were at a stable stage of treatment. Patients were randomly divided into a treatment group (n=19) and a control group (n=18). The treatment group received repetitive transcranial magnetic stimulation (rTMS) on the left prefrontal dorsolateral cortex (DLPFC), and the control group received placebo treatment. The number of cigarettes smoked were recorded at 7 days before treatment, during the course of treatment (i.e. for 21 days), and 3 weeks after treatment had ended. Assessments using the Positive and Negative Syndrome Scale (PANSS), Wisconsin Card Sorting Test (WCST), and Montgomery Asberg Depression Rating Scale (MADRS) were applied before and after treatment.

Result: Compared to the control group, the number of cigarettes smoked in the treatment group showed a statistically significant reduction in the first week after treatment. However, there was no significant correlation between the scores on PANSS, WCST and MADRS and the number of cigarettes smoked before and after treatment in both groups.

Discussion: High frequency (10Hz) repetitive transcranial magnetic stimulation on the left prefrontal cortex can reduce the number of cigarettes smoked in patients with schizophrenia.

Abstract Image

查看原文本刊更多论文

反复经颅磁刺激对精神分裂症患者吸烟的影响。

背景:精神分裂症患者的高吸烟率是一个重要的公共卫生问题，研究者一直在研究如何改变这一现状。目的:探讨高频(10Hz)重复经颅磁刺激对精神分裂症患者吸烟量的影响。方法:本研究招募了37例处于稳定治疗阶段的男性精神分裂症患者。患者随机分为治疗组(n=19)和对照组(n=18)。治疗组给予左前额叶背外侧皮层(DLPFC)重复经颅磁刺激(rTMS)，对照组给予安慰剂治疗。在治疗前7天、治疗过程中(即21天)和治疗结束后3周分别记录吸烟数量。治疗前后分别采用Positive and Negative Syndrome Scale (PANSS)、Wisconsin Card Sorting Test (WCST)和Montgomery Asberg Depression Rating Scale (MADRS)进行评估。结果:治疗组与对照组相比，治疗后第一周吸烟次数有统计学意义的减少。但两组患者治疗前后PANSS、WCST、MADRS评分与吸烟次数均无显著相关。讨论:高频(10Hz)重复经颅磁刺激左前额叶皮层可以减少精神分裂症患者吸烟的数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

上海精神医学

自引率

0.00%

发文量

2341

期刊介绍： Shanghai archives of psychiatry (bimonthly) was founded in 1959 and is sponsored by Shanghai Mental Health Center. The journal is aimed at mental health workers across the country, including psychiatrists and nurses, clinical psychologists, social workers, and people who are committed to the cause of mental health. It focuses on reporting clinical research results and practical experience in the field of psychiatry, and introduces the latest knowledge in psychiatry and related fields. The columns include monographs, case reports, clinical case discussions, reviews, mental health and law, and debates and discussions.