Effects of Transcranial Direct Current Stimulation (tDCS) for Auditory Hallucinations: A Systematic Review.

上海精神医学 Pub Date : 2016-12-25 DOI:10.11919/j.issn.1002-0829.216121

Haibin Li, Yiran Wang, Jiangling Jiang, Wei Li, Chunbo Li

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Abstract

Background: Transcranial direct current stimulation (tDCS) is a non-invasion brain stimulation, which has been suggested as a safe and promising treatment for auditory hallucinations, however, no systematic review has been conducted to evaluate the effects of tDCS on auditory hallucinations (AH).

Objective: To investigate the efficacy and safety of tDCS for auditory hallucinations among patients with schizophrenia.

Methods: We searched relevant randomized controlled trials (RCTs) from PubMed, EMBASE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chongqing VIP database for Chinese Technical Periodicals, WANFANG DATA, Chinese Biological Medical Literature Database, and Taiwan Electronic Periodical Services (TEPS) before February 13, 2016. Studies were selected based on pre-defined inclusion and exclusion criteria. The quality of each included study was assessed by the risk of bias table. The levels of evidence of primary outcomes were evaluated using GRADE criteria. Data synthesis was conducted using RevMan 5.3.

Results: 304 papers were screened. Finally, three studies with a combined sample size of 87 patients were included in the meta-analysis. Two studies were classified as having 'low risk of bias', one study was classified as having 'unclear'. Inconsistent results and the overall level of evidence of primary outcome was graded as 'low'.

Conclusions: The sample sizes of the published studies were small and the results were inconsistent. We could not draw any strong conclusions from these trials. Further high quality RCTs with large sample sizes are needed to assess the efficacy of tDCS for auditory hallucinations in patients with schizophrenia.

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经颅直流电刺激（tDCS）治疗听幻觉的效果：系统回顾。

背景：经颅直流电刺激（transcranial direct current stimulation，tDCS）是一种非侵入性脑刺激，被认为是治疗幻听的一种安全且有前景的方法，但目前还没有系统性的综述来评估tDCS对幻听（audioory hallucinations，AH）的影响：调查 tDCS 治疗精神分裂症患者幻听的有效性和安全性：我们检索了2016年2月13日之前PubMed、EMBASE、Cochrane图书馆、中国国家知识基础设施、中国科技期刊重庆VIP数据库、万方数据、中国生物医学文献数据库和台湾电子期刊服务（TEPS）中的相关随机对照试验（RCT）。研究根据预先设定的纳入和排除标准进行筛选。每项纳入研究的质量均通过偏倚风险表进行评估。主要结果的证据水平采用 GRADE 标准进行评估。使用 RevMan 5.3 进行数据综合：结果：共筛选出 304 篇论文。最后，有三项研究被纳入荟萃分析，其样本量合计为 87 例患者。其中两项研究被归类为 "低偏倚风险"，一项研究被归类为 "不明确"。结果不一致，主要结果的总体证据水平被评为 "低"：已发表研究的样本量较小，结果也不一致。我们无法从这些试验中得出任何有力的结论。我们需要进一步开展样本量较大的高质量 RCT 研究，以评估 tDCS 对精神分裂症患者幻听的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

上海精神医学

自引率

0.00%

发文量

2341

期刊介绍： Shanghai archives of psychiatry (bimonthly) was founded in 1959 and is sponsored by Shanghai Mental Health Center. The journal is aimed at mental health workers across the country, including psychiatrists and nurses, clinical psychologists, social workers, and people who are committed to the cause of mental health. It focuses on reporting clinical research results and practical experience in the field of psychiatry, and introduces the latest knowledge in psychiatry and related fields. The columns include monographs, case reports, clinical case discussions, reviews, mental health and law, and debates and discussions.