A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION.

African journal of traditional, complementary, and alternative medicines : AJTCAM Pub Date : 2017-06-05 eCollection Date: 2017-01-01 DOI:10.21010/ajtcam.v14i4.27

Li Sun, Dong-Hui Guo, Fei Liu, Qian Liu, Ning Jiang, Yun-Feng Sun, Li-Ping Cai, Hong-Xin Zheng

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引用次数: 3

Abstract

Background: Mammary hyperplasia is one of the most common benign breast disorders. Although traditional Chinese medicine has a vast experience in the treatment of mammary hyperplasia, it is not accepted widely due to its unclear mechanism.

Methods and materials: To address the mechanism, we developed a mouse model of mammary hyperplasia. We gave mice estradiol valerate tablets and progesterone capsules sequentially for one month by intragastric administration.

Results: Mice treated by this method had a series of pathological changes which are similar to those detected in women with mammary hyperplasia, including ectopic level of estradiol and progesterone in serum, hyperplasia of mammary glands and increased expression of ERα and PR.

Conclusion: This model will facilitate the mechanical study of traditional medicine on mammary hyperplasia.

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口服激素致小鼠乳腺增生模型。

背景:乳腺增生是最常见的乳腺良性疾病之一。虽然中医在治疗乳腺增生症方面有着丰富的经验，但由于其机制不明确，尚未被广泛接受。方法与材料:为探讨其作用机制，我们建立了小鼠乳腺增生模型。给小鼠戊酸雌二醇片和黄体酮胶囊，连续灌胃1个月。结果:经该方法处理的小鼠血清雌二醇、孕酮水平异位，乳腺增生，ERα、pr表达增加，均出现与乳腺增生相似的一系列病理变化。结论:该模型为传统药物治疗乳腺增生的力学研究提供了便利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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African journal of traditional, complementary, and alternative medicines : AJTCAM

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