Association between HMGB1 and asthma: a literature review.

Q2 Medicine

Clinical and Molecular Allergy Pub Date : 2017-06-14 eCollection Date: 2017-01-01 DOI:10.1186/s12948-017-0068-1

Egidio Imbalzano, Sebastiano Quartuccio, Eleonora Di Salvo, Teresa Crea, Marco Casciaro, Sebastiano Gangemi

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引用次数: 54

Abstract

Background: Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation.

Objective: This literature review aims to analyse advances on HMGB1 role, employment and potential diagnostic application in asthma.

Methods: We reviewed experimental studies that investigated the pathogenetic role of HMGB in bronchial airway hyper-responsiveness, inflammation and the correlation between HMGB1 level and asthma.

Results: A total of 19 studies assessing the association between HMGB1 and asthma were identified.

Conclusions: What emerged from this literature review was the confirmation of HMGB-1 involvement in diseases characterised by chronic inflammation, especially in pulmonary pathologies. Findings reported suggest a potential role of the alarmin in being a stadiation method and a marker of therapeutic efficacy; finally, inhibiting HMGB1 in humans in order to contrast inflammation should be the aim for future further studies.

Abstract Image

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HMGB1与哮喘的关系:文献综述。

背景:近年来，一些研究表明HMGB1作为警示蛋白家族的促炎介质，在不同的急慢性免疫疾病中起着关键作用。哮喘是一种复杂的疾病，其特征是与气道高反应性和气道炎症相关的反复和可逆性气流阻塞。目的:综述HMGB1在哮喘中的作用、应用及潜在诊断应用的研究进展。方法:回顾研究HMGB1在支气管气道高反应性、炎症中的致病作用以及HMGB1水平与哮喘的相关性的实验研究。结果:共有19项研究评估了HMGB1与哮喘之间的关系。结论:这篇文献综述证实了HMGB-1参与以慢性炎症为特征的疾病，特别是肺部疾病。报告的研究结果表明，警报素在作为一种固定方法和治疗效果的标记物方面具有潜在的作用;最后，抑制人类HMGB1以对抗炎症应该是未来进一步研究的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.