Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional Study.

International Scholarly Research Notices Pub Date : 2017-05-24 eCollection Date: 2017-01-01 DOI:10.1155/2017/6053267

Sheida Khosravani, Farhad Handjani, Reyhaneh Alimohammadi, Nasrin Saki

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引用次数: 15

Abstract

Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND).

Objective: The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients.

Methods: In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19.

Results: Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group (P = 0.022). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group (P = 0.008). In this study, the incidences of Parkinson's disease (P = 0.830), epilepsy (P = 0.067), and multiple sclerosis (P = 0.326) were not statistically significant between the two groups.

Conclusion: The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.

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大疱性类天疱疮患者神经系统疾病的频率:一项横断面研究。

背景:大疱性类天疱疮(BP)是一种常见于老年人的自身免疫性表皮下疱性皮肤病。一些研究报道了BP与神经系统疾病(ND)之间的联系。目的:本研究的目的是评估伊朗患者BP与神经系统疾病之间的关系。方法:在这项横断面研究中，87例BP患者入组。他们与184个对照组进行了比较。采用SPSS统计软件19版进行统计分析。结果:87例BP患者中，17例(19.5%)至少有一种神经系统疾病。脑血管意外(CVA)是最常见的神经系统疾病，病例组7例(8.0%)，对照组4例(2.1%)。BP组与对照组CVA发生率差异有统计学意义(P = 0.022)。病例组痴呆6例(16.8%)，对照组痴呆2例(1.0%)。BP组痴呆发生率与对照组比较差异有统计学意义(P = 0.008)。本研究中，两组帕金森病(P = 0.830)、癫痫(P = 0.067)、多发性硬化症(P = 0.326)的发病率比较，差异均无统计学意义。结论:BP患者CVA和痴呆的发生率明显高于对照组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Scholarly Research Notices

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