Optimal threshold of stimulated serum thyroglobulin level for ¹⁸F-FDG PET/CT imaging in patients with thyroid cancer.

Q Engineering

Journal of Huazhong University of Science and Technology [Medical Sciences] Pub Date : 2017-06-01 Epub Date: 2017-06-06 DOI:10.1007/s11596-017-1752-6

Hong Chai, Hu Zhang, Yong-Li Yu, Yun-Chao Gao

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引用次数: 1

Abstract

This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH)-stimulated serum thyroglobulin (s-Tg) for patients who were to receive ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer (DTC) recurrence but negative post-therapeutic ¹³¹I whole-body scan (¹³¹I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic (ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values (SUVmax) of ¹⁸F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of ¹⁸F-FDG. So, positive PET/CT imaging is expected when patients have negative ¹³¹I-WBS but s-Tg levels over 49 μg/L.

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甲状腺癌患者18F-FDG PET/CT显像刺激血清甲状腺球蛋白水平的最佳阈值

本研究旨在探讨因临床怀疑分化型甲状腺癌(DTC)复发而接受18f -氟脱氧葡萄糖(18F-FDG) PET/CT扫描，治疗后131I全身扫描(131I- wbs)阴性的患者，促甲状腺激素(TSH)刺激的血清甲状腺球蛋白(s-Tg)的最佳阈值。2010年10月至2014年7月，共60例符合条件的患者接受了PET/CT扫描。受试者工作特征(ROC)曲线分析显示，s-Tg水平大于49 μg/L时，PET/CT诊断复发的准确率最高，敏感性为89.5%，特异性为90.9%。此外，双变量相关分析显示，PET/CT扫描阳性患者s-Tg水平与18F-FDG的最大标准化摄取值(SUVmax)呈正相关，提示TSH对Tg释放和18F-FDG摄取均有显著影响。因此，当患者131I-WBS呈阴性，但s-Tg水平超过49 μg/L时，PET/CT表现为阳性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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