Protective effect of Hesperidin and Tiger nut against Acrylamide toxicity in female rats

Q2 Medicine

Experimental and Toxicologic Pathology Pub Date : 2017-10-02 DOI:10.1016/j.etp.2017.05.004

Soha M. Hamdy , Amany M. Shabaan , Abdel Karim M. Abdel Latif , Ayman M. Abdel-Aziz , Alshimaa M. Amin

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引用次数: 37

Abstract

Phytochemicals that have antioxidant effect play important role in protection against several diseases in humans. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the early changes that may be related to the toxicity of acrylamide in female rats. 72 Sprague Dawley female rats were divided into six groups (12 rat/group): control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI). There was a significant increase in the levels of serum carcino embryonic antigen (CEA), malondialdehyde (MDA), protein carbonyls (CO), ALT, AST, LDH, urea and creatinine while no significant changes of serum total sialic acid, progesterone (prog) and estradiol (E2) levels, and significant decreases of body weights, catalase (Cat) activity, superoxide dismutase (SOD) activity, reduced glutathione (GSH) level, and glutathione peroxidase (GSH-Px) activity of ACR treated group compared with the control. Our results suggested that supplementation of a diet with hesperidin provided antioxidant defense more significant than tiger nut against the toxicity of ACR in breast, liver and kidney tissues.

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橙皮苷和虎果对雌性大鼠丙烯酰胺毒性的保护作用

具有抗氧化作用的植物化学物质在预防人类多种疾病中发挥着重要作用。本研究旨在探讨橙皮苷和虎果对丙烯酰胺毒性引起的雌性大鼠早期病变的影响。72只雌性Sprague Dawley大鼠分为6组，每组12只:对照组(I);橙皮苷(HES)处理组(II);虎坚果(TN)处理组(III);丙烯酰胺(ACR)处理组(IV);HES-ACR处理组(V);n - acr处理组(VI)血清癌胚抗原(CEA)、丙二醛(MDA)、蛋白羰基(CO)、ALT、AST、LDH、尿素和肌酐水平显著升高，血清总唾液酸、孕酮(prog)和雌二醇(E2)水平无显著变化，体重、过氧化氢酶(Cat)活性、超氧化物歧化酶(SOD)活性、还原型谷胱甘肽(GSH)水平显著降低。ACR处理组的谷胱甘肽过氧化物酶(GSH-Px)活性显著高于对照组。本研究结果提示，添加橙皮苷对小鼠乳腺、肝脏和肾脏组织的抗氧化防御作用强于虎坚果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental and Toxicologic Pathology 医学-病理学

CiteScore

2.08

自引率

0.00%

发文量

审稿时长

5.3 weeks

期刊介绍： Cessation. The international multidisciplinary journal is devoted to the publication of studies covering the whole range of experimental research on disease processes and toxicology including cell biological investigations. Its aim is to support progress in the interdisciplinary cooperation of researchers working in pathobiology, toxicology, and cell biology independent of the methods applied. During the past decades increasing attention has been paid to the importance of toxic influence in the pathogenesis of human and animal diseases. This is why Experimental and Toxicologic Pathology meets the urgent need for an interdisciplinary journal felt by a wide variety of experts in medicine and biology, including pathologists, toxicologists, biologists, physicians, veterinary surgeons, pharmacists, and pharmacologists working in academic, industrial or clinical institutions.