Molluscum Contagiosum: An Update.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
Alexander K C Leung, Benjamin Barankin, Kam L E Hon
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引用次数: 55

Abstract

Background: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition.

Objective: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum.

Methods: A PubMed search was completed in Clinical Queries using the key term "molluscum contagiosum". Patents were searched using the key term "molluscum contagiosum" from www.google.com/patents, http: //espacenet.com, and www.freepatentsonline.com.

Results: Molluscum contagiosum is caused by a poxvirus of the Molluscipox genus. Preschool and elementary school-aged children are more commonly affected. The virus is transmitted by close physical contact, autoinoculation, and fomites. Typically, molluscum contagiosum presents as asymptomatic, discrete, smooth, flesh-colored, dome-shaped papules with central umbilication from which a plug of cheesy material can be expressed. Some authors suggest watchful waiting of the lesions.Many authors suggest active treatment of lesions for cosmetic reasons or concerns of transmission and autoinoculation. Active treatments may be mechanical (e.g. cryotherapy, curettage, pulsed dye laser therapy), chemical (e.g. cantharidin, potassium hydroxide, podophyllotoxin, benzoyl peroxide, tretinoin, trichloroacetic acid, lactic acid, glycolic acid, salicylic acid), immune-modulating (e.g. imiquimod, interferon-alpha, cimetidine) and anti-viral (e.g. cidofovir). Recent patents related to the management of molluscum contagiosum are also retrieved and discussed. These patents comprise of topical compositions and herbal Chinese medicine with limited documentation of their efficacy.

Conclusion: The choice of treatment method should depend on the physician's comfort level with the various treatment options, the patient's age, the number and severity of lesions, location of lesions, and the preference of the child/parents. In general, physical destruction of the lesion, in particular, cryotherapy with liquid nitrogen and chemical destruction with cantharidin are the methods of choice for the majority of patients.

传染性软体动物:更新。
背景:传染性软疣是一种在世界范围内发生的儿童病毒性皮肤感染。医生应该熟悉这种常见病。目的:综述传染性软疣的流行病学、病理生理、临床表现、并发症及治疗方法。方法:在“临床查询”中以“传染性软疣”为关键词进行PubMed检索。使用关键词“传染性软疣”从www.google.com/patents, http: //espacenet.com和www.freepatentsonline.com.Results上检索专利:传染性软疣是由一种软疣属痘病毒引起的。学龄前和小学学龄儿童更常受到影响。该病毒通过密切的身体接触、自身接种和污染物传播。通常,传染性软疣表现为无症状,离散,光滑,肉色,圆顶状丘疹,中央脐部可表现出奶酪样物质的塞。一些作者建议观察等待病变。许多作者建议积极治疗病变的美容原因或担心传播和自身接种。主动治疗可以是机械治疗(如冷冻治疗、刮除、脉冲染料激光治疗)、化学治疗(如斑斑素、氢氧化钾、鬼臼毒素、过氧化苯甲酰、维甲酸、三氯乙酸、乳酸、乙醇酸、水杨酸)、免疫调节治疗(如咪喹莫特、干扰素α、西咪替丁)和抗病毒治疗(如西多福韦)。本文还检索并讨论了有关传染性软疣治疗的最新专利。这些专利包括局部组合物和中草药,其功效的文件有限。结论:治疗方法的选择应取决于医生对各种治疗方案的舒适度、患者的年龄、病变的数量和严重程度、病变的位置以及儿童/家长的偏好。一般来说,对病变进行物理破坏,特别是液氮冷冻治疗和斑蝥素化学破坏是大多数患者的选择方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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