Graphical Modeling Meets Systems Pharmacology.

Gene regulation and systems biology Pub Date : 2017-03-10 eCollection Date: 2017-01-01 DOI:10.1177/1177625017691937
Rosario Lombardo, Corrado Priami
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引用次数: 4

Abstract

A main source of failures in systems projects (including systems pharmacology) is poor communication level and different expectations among the stakeholders. A common and not ambiguous language that is naturally comprehensible by all the involved players is a boost to success. We present bStyle, a modeling tool that adopts a graphical language close enough to cartoons to be a common media to exchange ideas and data and that it is at the same time formal enough to enable modeling, analysis, and dynamic simulations of a system. Data analysis and simulation integrated in the same application are fundamental to understand the mechanisms of actions of drugs: a core aspect of systems pharmacology.

Abstract Image

Abstract Image

Abstract Image

图形建模满足系统药理学。
系统项目(包括系统药理学)失败的主要原因是沟通水平差和涉众之间的不同期望。所有参与者都能自然理解的通用且不模棱两可的语言有助于推动成功。我们介绍了bStyle,这是一种建模工具,它采用了一种与漫画非常接近的图形语言,作为交换思想和数据的通用媒体,同时它也足够正式,可以对系统进行建模、分析和动态模拟。在同一应用程序中集成数据分析和模拟是理解药物作用机制的基础:系统药理学的核心方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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