Stephen T Mennemeyer, Joseph E Schumacher, Jesse B Milby, Dennis Wallace
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引用次数: 0
Abstract
Background: Between 1990 and 2006 in Birmingham, Alabama USA, 4 separate randomized controlled studies, called "Homeless 1" through "Homeless 4", treated cocaine substance abuse among chronically homeless adults, largely black men, many with non-psychotic mental health problems. The 4 studies had 9 treatment arms that used various counseling methods plus, in some arms, the provision of housing and work therapy usually with a contingent requirement of urine-test verified abstinence from substances. Participants in the abstinent-contingent arms who lapsed on abstinence were removed from housing and sent to an evening public shelter from which they were daily transported to day treatment until they returned to abstinence.
Aims of the study: This paper compares the cost effectiveness of the treatment arms.
Methods: Societal cost per participant (in 2014 dollars) for each arm is defined as direct treatment cost plus cost of jail or hospital plus societal expense of public shelter use by lapsed participants. An untreated Base Case is defined as 5 percent abstinence with 95 percent usage of a public shelter. Incremental Cost Effectiveness Ratios (ICERs) for paired arms are defined as the change in cost per participant divided by the change in abstinence. Bootstrapping estimates confidence intervals.
Results: Average cost per participant at the end of 6 months of active treatment in 7 arms with comparable data ranged from USD 10,447 to USD 36,194 with corresponding average weeks abstinent ranging from 6.1 to 15.3 out of a possible 26 weeks. In contrast, the Base Case would cost USD 6,123 for 1.3 weeks of abstinence. Compared to the Base Case, the least expensive "DT2" treatment has an ICER of USD 901 (95% CI = USD 571 to USD 1,681) per additional week of abstinence and the most expensive "CMP4" has an ICER of USD 2,147 (95% CI = USD 1,701 to USD 2,848). Additionally, the Homeless 3 study found that the abstinent contingent housing (ACH3) treatment compared to the Non Abstinent Contingent Housing (NAC3), analogous to "Housing First", achieved better abstinence (12.1 v. 10 weeks) at higher average cost (USD 22,512 v. USD 17,541) yielding an ICER for this comparison of (USD 2,367, 95% CI=USD -10,587 to USD 12,467). Similar results are found at 12 months (6 months after active treatment).
Discussion: More intensive methods of counseling improved abstinence but 4 of the 7 treatments were inefficient ("dominated"). Bootstrapping shows that results are sensitive to which individuals were randomly assigned to each arm. A limitation of the analysis is that it does not consider the full societal cost of lost wages, crime costs beyond jail expenses and deterioration of neighborhood quality of life. Additionally, populations treated by Housing First programs may differ from the Birmingham Homeless studies in the severity of addiction or co-occuring psychological problems.
Implications for treatment: The Homeless studies show that abstinent contingent safe housing with counseling can substantially improve abstinence for homeless cocaine abusers. Incremental costs rise sharply with more intensive counseling; modest programs of counseling may be more cost effective in a stepped treatment strategy.
背景:1990年至2006年间,在美国阿拉巴马州伯明翰进行了4项独立的随机对照研究,称为“无家可归者1”到“无家可归者4”,对长期无家可归的成年人(主要是黑人男性)中的可卡因药物滥用进行了治疗,其中许多人患有非精神病性精神健康问题。这4项研究有9个治疗组,使用各种咨询方法,在一些组中,提供住房和工作治疗,通常附带尿检证实戒断物质的要求。戒瘾小组中戒瘾失败的参与者被从住房中移走,送到一个晚间公共庇护所,每天从那里接受日间治疗,直到他们恢复戒瘾。研究目的:本文比较了治疗组的成本效益。方法:每个分支的每个参与者的社会成本(2014年美元)定义为直接治疗成本加上监狱或医院成本加上失效参与者使用公共庇护所的社会费用。未经治疗的基本病例被定义为5%的禁欲,95%的人使用公共庇护所。配对组的增量成本效果比(ICERs)定义为每个参与者的成本变化除以戒断的变化。自举估计置信区间。结果:在7个组的6个月积极治疗结束时,每位参与者的平均成本从10,447美元到36,194美元不等,相应的平均戒断周数从6.1到15.3周不等(可能的26周)。相比之下,基本情况下,1.3周的禁欲将花费6123美元。与基础病例相比,最便宜的“DT2”治疗的ICER为901美元(95% CI = 571美元至1,681美元),而最昂贵的“CMP4”治疗的ICER为2,147美元(95% CI = 1,701美元至2,848美元)。此外,无家可归者3研究发现,与类似于“住房优先”的非禁欲临时住房(NAC3)相比,禁欲临时住房(ACH3)治疗以更高的平均成本(22,512美元对17,541美元)实现了更好的禁欲(12.1 vs 10周),因此比较的ICER为(2,367美元,95% CI= -10,587美元至12,467美元)。在12个月(积极治疗后6个月)发现类似的结果。讨论:更密集的咨询方法改善了戒断,但7种治疗方法中有4种是无效的(“主导”)。Bootstrapping表明,结果对随机分配到每个手臂的个体很敏感。该分析的一个局限性在于,它没有考虑工资损失的全部社会成本、监狱费用之外的犯罪成本以及社区生活质量的恶化。此外,住房优先项目治疗的人群在成瘾或共同发生的心理问题的严重程度上可能与伯明翰无家可归者研究不同。对治疗的启示:无家可归者的研究表明,戒断临时安全住房与咨询可以大大提高戒断无家可归的可卡因滥用者。随着咨询的深入,增量成本急剧上升;适度的咨询计划在阶梯式治疗策略中可能更具成本效益。
期刊介绍:
The Journal of Mental Health Policy and Economics publishes high quality empirical, analytical and methodologic papers focusing on the application of health and economic research and policy analysis in mental health. It offers an international forum to enable the different participants in mental health policy and economics - psychiatrists involved in research and care and other mental health workers, health services researchers, health economists, policy makers, public and private health providers, advocacy groups, and the pharmaceutical industry - to share common information in a common language.