Intra-articular injection with triamcinolone hexacetonide in patients with rheumatoid arthritis: prospective assessment of goniometry and joint inflammation parameters

Revista Brasileira de Reumatologia (English Edition) Pub Date : 2017-03-01 DOI:10.1016/j.rbre.2016.08.001

Rita Nely Vilar Furtado, Flávia Soares Machado, Karine Rodrigues da Luz, Marla Francisca dos Santos, Monique Sayuri Konai, Roberta Vilela Lopes, Jamil Natour

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引用次数: 15

Abstract

Objectives

To evaluate local joint variables after intra-articular injection with triamcinolone hexacetonide in rheumatoid arthritis patients.

Methods

We blindly and prospectively (baseline, 1, 4, 12 and 24 weeks) evaluated metacarpophalangeal, wrist, elbow, shoulder, knee and ankle joints after triamcinolone hexacetonide intra-articular injection by the following outcome measures: visual analogue scale 0–10 cm (VAS) for rest pain (VASR); VAS for movement pain (VASM); VAS for joint swelling (VASSw); flexion (FlexG) and extension (ExtG).

Results

289 patients (635 joints) were studied. VASSw (p < 0.001) and VASR (0.001 < p < 0.016) improved from T0 to T4, T12 and T24 for all joints. VASM improved from T0 to T4 (p < 0.021) for all joints; T0 to T12 (p < 0.023) for MCF and knee; T0 to T24 (p < 0.019) only for MCF and knee. FlexG improved from T0 to T4 (p < 0.001) for all joints; T0 to T12 (p < 0.001) and T0 to T24 (p < 0.02) only for MCF and knee. ExtG improved from T0 to T4 (p < 0.001) for all joints except for elbow; T0 to T12 (p = 0.003) for wrist, metacarpophalangeal and knee; and T0 to T24 (p = 0.014) for MCF and knee.

Conclusion

VASSw responded better at short and medium term after IAI with triamcinolone hexacetonide in our sample of RA patients.

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类风湿性关节炎患者关节内注射曲安奈德:角度测量和关节炎症参数的前瞻性评估

目的评价类风湿性关节炎患者关节内注射曲安奈德后局部关节变化。方法采用盲法和前瞻性(基线、1、4、12和24周)评价六曲安奈德关节内注射后掌指关节、腕关节、肘关节、肩关节、膝关节和踝关节的预后指标:静止疼痛的视觉模拟评分0-10 cm (VAS);VAS治疗运动痛(VASM);关节肿胀VAS (vasw);屈(FlexG)和伸(ExtG)。结果289例患者共635个关节。w & p;0.001)和VASR (0.001 <p & lt;0.016)，各关节从T0到T4、T12和T24均有改善。VASM从T0提高到T4 (p <所有接头0.021);T0至T12 (p <MCF和膝关节0.023);T0至T24 (p <0.019)仅适用于MCF和膝关节。FlexG从T0改善到T4 (p <0.001);T0至T12 (p <0.001)和T0 ~ T24 (p <0.02)，仅适用于MCF和膝关节。ExtG从T0提高到T4 (p <0.001)，除肘关节外的所有关节;腕、掌指骨、膝关节T0 ~ T12 (p = 0.003);MCF和膝关节T0 ~ T24 (p = 0.014)。结论在我们的RA患者样本中，使用曲安奈德进行IAI后，vassw的中短期疗效更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista Brasileira de Reumatologia (English Edition)

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