Angiotensin-Converting Enzyme Ins/Del Polymorphism and Body Composition: The Intermediary Role of Hydration Status.

Q Agricultural and Biological Sciences

Journal of Nutrigenetics and Nutrigenomics Pub Date : 2017-01-01 Epub Date: 2017-03-18 DOI:10.1159/000458154

Laura Bordoni, Valerio Napolioni, Francesca Marchegiani, Emilio Amadio, Rosita Gabbianelli

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引用次数: 4

Abstract

Background: The well-known insertion/deletion polymorphism (rs4646994) of the angiotensin-converting enzyme (ACE) gene has been previously associated with obesity, blood flow, muscular strength, and ACE enzyme activity. Despite the relevant role of ACE in homeostasis, few data are currently available on the relationship between rs4646994 and hydration status. Thus, we tested the association between the ACE Ins/Del polymorphism, body composition, and hydration status in a young Italian population.

Methods: A total of 306 healthy children and adolescents who regularly practice sports were recruited. Anthropometric, bioimpedentiometric parameters, and urine samples were collected, while ACE rs4646994 genotyping was performed on DNA from buccal swabs. General linear models were used for association testing.

Results: The ACE Ins/Del polymorphism was associated with body composition. Ins/Ins individuals had higher phase angle (PhA) and body cellular mass index (BCMI) values. A significant influence of the ACE rs4646994 according to hydration status on body composition was also identified. In particular, Ins/Ins individuals displayed higher PhA and BCMI values only if norm-hydrated, while they showed values similar to Del carriers if dehydrated.

Conclusion: Our results confirm the relationship between the ACE Ins/Del polymorphism and body composition and suggest a role for hydration status in modulating this relationship. These interesting preliminary results warrant further investigation to disentangle the genetic role of ACE on hydration homeostasis.

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血管紧张素转换酶Ins/Del多态性与机体组成:水合状态的中介作用。

背景:众所周知的血管紧张素转换酶(ACE)基因的插入/缺失多态性(rs4646994)先前与肥胖、血流量、肌肉力量和ACE酶活性有关。尽管ACE在体内平衡中有相关作用，但目前关于rs4646994与水合状态之间关系的数据很少。因此，我们在意大利年轻人中测试了ACE Ins/Del多态性、身体成分和水合状态之间的关系。方法:共招募了306名经常进行体育锻炼的健康儿童和青少年。收集人体测量学、生物阻抗学参数和尿液样本，同时对口腔拭子DNA进行ACE rs4646994基因分型。关联检验采用一般线性模型。结果:ACE Ins/Del多态性与体成分相关。Ins/Ins个体具有较高的相位角(PhA)和身体细胞质量指数(BCMI)。根据水合状态确定ACE rs4646994对体成分有显著影响。特别是，Ins/Ins个体只有在正常水合状态下才显示出较高的PhA和BCMI值，而在脱水状态下则显示出与Del携带者相似的值。结论:我们的研究结果证实了ACE Ins/Del多态性与身体成分之间的关系，并表明水合状态在调节这一关系中起作用。这些有趣的初步结果值得进一步研究，以解开ACE在水合稳态中的遗传作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.