Evidence of AS3MTd2d3-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders.

Abstract

Genome-wide association studies suggest that 10q24.32-33 is a risk region for schizophrenia (SCZ). Considering the substantial genetic overlap between SCZ and major affective disorders, we would like to investigate whether the 10q24.32-33 region confers risk of affective disorders. We chose three SCZ genome-wide significant SNPs (rs7914558, rs7085104, and rs11191580) in 10q24.32-33 and collected the statistical data from European and Asian populations to perform systematic meta-analyses, which finally included up to 26,413 cases with affective disorders and 24,849 controls. Meta-analyses showed that all SNPs were nominally associated with major affective disorders. Considering the a priori evidence that these SNPs were associated with the expression of AS3MT^d2d3 isoform in the human brain, our data confirms the potential involvement of AS3MT^d2d3 in the genetic risk of major affective disorders.