The potential of cystatin-C to evaluate the prognosis of acute heart failure: A comparative study.

Acute cardiac care Pub Date : 2015-12-01 Epub Date: 2016-08-05 DOI:10.1080/17482941.2016.1203440
Tae-Hun Kim, Hyungseop Kim, In-Cheol Kim
{"title":"The potential of cystatin-C to evaluate the prognosis of acute heart failure: A comparative study.","authors":"Tae-Hun Kim,&nbsp;Hyungseop Kim,&nbsp;In-Cheol Kim","doi":"10.1080/17482941.2016.1203440","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The prognosis of acute heart failure (HF) can be determined by cardio-renal function which is assessed by cystatin-C (Cys-C). We evaluated whether Cys-C could be a more useful prognostic indicator in acute HF, compared with uric acid (UA) and N-terminal pro-B-type natriuretic peptide (NT-proBNP).</p><p><strong>Methods: </strong>Two hundred thirty-two HF patients in the emergency room were studied using measurements of Cys-C, UA, and NT-proBNP. During the follow-up, cardiac events, defined as the composites of recurrent HF or cardiac death, were determined.</p><p><strong>Results: </strong>Seventy-seven cardiac events (28 cardiac deaths, 49 recurrent HFs) occurred over two years. The events group revealed higher levels of Cys-C, UA, and NT-proBNP. They showed increased blood urea nitrogen and creatinine, reduced septal tissue Doppler velocity (TVI-Sm), and low frequencies of beta-blockers (BB), diuretics and angiotensin-converting enzyme inhibitors/-receptor blockers. Cys-C (the best cutoff: 1.7 mg/l) had a steady, persistent hazard ratio (HR) over two years. On multivariate analysis, Cys-C, TVI-Sm, and BB were significant predictors for adverse events. Cys-C provided an incremental value for prognosis more than NT-proBNP and UA did over the follow-up period.</p><p><strong>Conclusions: </strong>Compared with UA and NT-proBNP, Cys-C could be better prognostic biomarker for cardiac events two years after acute HF.</p>","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"17 4","pages":"72-76"},"PeriodicalIF":0.0000,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/17482941.2016.1203440","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acute cardiac care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17482941.2016.1203440","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/8/5 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14

Abstract

Background: The prognosis of acute heart failure (HF) can be determined by cardio-renal function which is assessed by cystatin-C (Cys-C). We evaluated whether Cys-C could be a more useful prognostic indicator in acute HF, compared with uric acid (UA) and N-terminal pro-B-type natriuretic peptide (NT-proBNP).

Methods: Two hundred thirty-two HF patients in the emergency room were studied using measurements of Cys-C, UA, and NT-proBNP. During the follow-up, cardiac events, defined as the composites of recurrent HF or cardiac death, were determined.

Results: Seventy-seven cardiac events (28 cardiac deaths, 49 recurrent HFs) occurred over two years. The events group revealed higher levels of Cys-C, UA, and NT-proBNP. They showed increased blood urea nitrogen and creatinine, reduced septal tissue Doppler velocity (TVI-Sm), and low frequencies of beta-blockers (BB), diuretics and angiotensin-converting enzyme inhibitors/-receptor blockers. Cys-C (the best cutoff: 1.7 mg/l) had a steady, persistent hazard ratio (HR) over two years. On multivariate analysis, Cys-C, TVI-Sm, and BB were significant predictors for adverse events. Cys-C provided an incremental value for prognosis more than NT-proBNP and UA did over the follow-up period.

Conclusions: Compared with UA and NT-proBNP, Cys-C could be better prognostic biomarker for cardiac events two years after acute HF.

胱抑素c评价急性心力衰竭预后的潜力:一项比较研究。
背景:急性心力衰竭(HF)的预后可以通过心肾功能来确定,心肾功能通过胱抑素c (Cys-C)来评估。与尿酸(UA)和n端前b型利钠肽(NT-proBNP)相比,我们评估了Cys-C是否可以作为急性心衰更有用的预后指标。方法:采用Cys-C、UA和NT-proBNP测量方法对急诊房内的232例HF患者进行研究。在随访期间,确定心脏事件,定义为复发性心衰或心源性死亡的复合。结果:两年内发生了77例心脏事件(28例心脏性死亡,49例复发性心力衰竭)。事件组显示更高水平的Cys-C、UA和NT-proBNP。他们表现出血尿素氮和肌酐升高,室间隔组织多普勒速度(TVI-Sm)降低,β受体阻滞剂(BB)、利尿剂和血管紧张素转换酶抑制剂/受体阻滞剂的低频率。Cys-C(最佳临界值:1.7 mg/l)在两年内具有稳定、持续的风险比(HR)。在多变量分析中,Cys-C、TVI-Sm和BB是不良事件的显著预测因子。在随访期间,Cys-C比NT-proBNP和UA对预后的影响更大。结论:与UA和NT-proBNP相比,Cys-C可能是急性HF后两年更好的心脏事件预后生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信