Age, Comorbidity, Frailty in Observational and Analytic Studies of Neurological Diseases.

Q3 Medicine

Frontiers of Neurology and Neuroscience Pub Date : 2016-01-01 Epub Date: 2016-07-26 DOI:10.1159/000445414

Jan Novy, Josemir W Sander

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引用次数: 2

Abstract

Background: Comorbidities are rarely taken into account in studies of neurological conditions although they may be a confounder of the outcome and treatment. The relationship between comorbidities and neurological conditions is also problematic as comorbidities may be symptoms of the underlying cause of the neurologic condition or long-term adverse effects of the treatment.

Summary: There is evidence that several common neurological conditions have an increased burden of somatic and psychiatric comorbidities compared with matched samples from the general population. Depression is probably the most common comorbidity. Both psychiatric and somatic comorbidities have been shown to account for some of the premature mortality encountered in these neurological conditions. Comorbidities and age can also be important factors in the response and tolerance to treatment, and can alter the general outcome of a disease.

Key messages: Age and comorbidities should not be overlooked in the observation and assessment of neurological conditions and their treatment.

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神经系统疾病观察与分析研究中的年龄、共病、虚弱。

背景:在神经系统疾病的研究中很少考虑到合并症，尽管它们可能是结果和治疗的混杂因素。合并症与神经系统疾病之间的关系也是有问题的，因为合并症可能是神经系统疾病潜在原因的症状或治疗的长期不良反应。总结:有证据表明，与来自普通人群的匹配样本相比，几种常见的神经系统疾病有增加的躯体和精神合并症负担。抑郁症可能是最常见的合并症。精神和躯体合并症已被证明是这些神经系统疾病中遇到的一些过早死亡的原因。合并症和年龄也是影响对治疗的反应和耐受性的重要因素，并可能改变疾病的一般结果。关键信息:在观察和评估神经系统疾病及其治疗时，年龄和合并症不应被忽视。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers of Neurology and Neuroscience Medicine-Neurology (clinical)

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期刊介绍： Focusing on topics in the fields of both Neurosciences and Neurology, this series provides current and unique information in basic and clinical advances on the nervous system and its disorders.