Thimerosal-containing Hepatitis B Vaccine Exposure is Highly Associated with Childhood Obesity: A Case-control Study Using the Vaccine Safety Datalink.

David A Geier, Janet K Kern, Kristin G Homme, Lisa K Sykes, Mark R Geier
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Abstract

Background: Obesity among children and adolescents in the United States has tripled since 1980, and has become a major public health concern.

Aims: The purpose of this study was to evaluate the potential relationship between exposure to organic mercury from Thimerosal-containing hepatitis B vaccines and the children's subsequent risk of an obesity diagnosis.

Materials and methods: A hypothesis-testing, case-control study was undertaken to evaluate exposure to organic mercury from Thimerosal-containing hepatitis B vaccines, which were administered at specific intervals in the first 6 months of life, among cases diagnosed with childhood obesity and controls by examining automated medical records for children born from 1991 to 2000 who were continuously enrolled in the Vaccine Safety Datalink database.

Results: This study found highly significant associations as follows. Cases diagnosed with obesity were significantly (P < 0.00001) more likely to have received greater exposure to organic mercury from Thimerosal-containing hepatitis B vaccines administered within the first month of life (odds ratio (OR) =1.511), first 2 months of life (OR = 1.486), and first 6 months of life (OR = 3.795) than the controls. Similar outcomes were observed when the overall data were separated by gender. In a dose-response manner, cases diagnosed with obesity were significantly more likely than controls to have received greater exposure to organic mercury from Thimerosal-containing hepatitis B vaccines, which were administered within the first 6 months of life (OR = 1.0375 per μg of mercury, P < 0.00001).

Conclusions: In a dose-response manner, the present study associates an increased organic mercury exposure from Thimerosal-containing hepatitis B vaccines with an increased risk of obesity diagnosis, and suggests that Thimerosal is an obesogen. The results are biologically plausible and future studies are needed to examine this phenomenon.

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暴露于含硫柳汞的乙肝疫苗与儿童肥胖症高度相关:利用疫苗安全数据链进行的病例对照研究》(A Case-control Study Using the Vaccine Safety Datalink)。
背景:目的:本研究旨在评估暴露于含硫柳汞的乙型肝炎疫苗中的有机汞与儿童随后被诊断为肥胖症的风险之间的潜在关系:我们进行了一项假设检验、病例对照研究,通过检查1991年至2000年期间出生并连续加入疫苗安全数据链接数据库的儿童的自动医疗记录,评估儿童肥胖症病例和对照组在出生后6个月内接种的含硫柳汞乙型肝炎疫苗中有机汞的暴露情况:这项研究发现了以下非常重要的关联。与对照组相比,确诊为肥胖症的病例在出生后 1 个月内接种含硫柳汞的乙型肝炎疫苗(几率比 (OR) =1.511)、出生后 2 个月内接种含硫柳汞的乙型肝炎疫苗(OR =1.486)和出生后 6 个月内接种含硫柳汞的乙型肝炎疫苗(OR =3.795)时更有可能接触到更多有机汞(P < 0.00001)。如果按性别对总体数据进行分类,也能观察到类似的结果。从剂量反应的角度看,确诊为肥胖症的病例比对照组更有可能从出生后 6 个月内接种的含硫柳汞的乙型肝炎疫苗中摄入更多的有机汞(OR = 1.0375 per μg mercury,P < 0.00001):本研究以剂量反应的方式将含硫柳汞的乙肝疫苗中有机汞暴露量的增加与肥胖诊断风险的增加联系起来,并表明硫柳汞是一种肥胖原。这些结果在生物学上是可信的,今后需要对这一现象进行研究。
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