The Chief Role of Frontal Operational Module of the Brain Default Mode Network in the Potential Recovery of Consciousness from the Vegetative State: A Preliminary Comparison of Three Case Reports.

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2016-05-13 eCollection Date: 2016-01-01 DOI:10.2174/1874440001610010041
Alexander A Fingelkurts, Andrew A Fingelkurts, Sergio Bagnato, Cristina Boccagni, Giuseppe Galardi
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引用次数: 16

Abstract

It has been argued that complex subjective sense of self is linked to the brain default-mode network (DMN). Recent discovery of heterogeneity between distinct subnets (or operational modules - OMs) of the DMN leads to a reconceptualization of its role for the experiential sense of self. Considering the recent proposition that the frontal DMN OM is responsible for the first-person perspective and the sense of agency, while the posterior DMN OMs are linked to the continuity of 'I' experience (including autobiographical memories) through embodiment and localization within bodily space, we have tested in this study the hypothesis that heterogeneity in the operational synchrony strength within the frontal DMN OM among patients who are in a vegetative state (VS) could inform about a stable self-consciousness recovery later in the course of disease (up to six years post-injury). Using EEG operational synchrony analysis we have demonstrated that among the three OMs of the DMN only the frontal OM showed important heterogeneity in VS patients as a function of later stable clinical outcome. We also found that the frontal DMN OM was characterized by the process of active uncoupling (stronger in persistent VS) of operations performed by the involved neuronal assemblies.

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脑默认模式网络额叶操作模块在植物人意识潜在恢复中的主要作用:三例报告的初步比较。
复杂的主观自我意识与大脑的默认模式网络(DMN)有关。最近发现DMN的不同子网(或操作模块- OMs)之间的异质性导致其对自我体验感的角色的重新概念化。考虑到最近的一个命题,即前额DMN OM负责第一人称视角和代理感,而后部DMN OM通过身体空间的具体化和定位与“我”体验(包括自传体记忆)的连续性联系在一起,我们在本研究中检验了一种假设,即植物人状态(VS)患者前额DMN OM内操作同步强度的异质性可能会影响疾病后期(损伤后长达6年)稳定的自我意识恢复。通过脑电图操作同步分析,我们已经证明,在DMN的三个OM中,只有额部OM在VS患者中表现出重要的异质性,作为后来稳定临床结果的功能。我们还发现,额叶DMN OM的特征是参与的神经元组合所执行的操作的主动解耦过程(在持续VS中更强)。
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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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