[Morphological and Physiological Properties of the Micromycete Arthrobotrys longa, a Producer of Longolytin, a Proteolytic Complex with a Thrombolytic Effect].
T S Sharkova, E I Kornienko, A A Osmolovskiy, V G Kreier, N A Baranova, N S Egorov
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引用次数: 0
Abstract
Production of proteinases with plasmin-like and plasminogen-activating activities by a micromycete Arthrobotrys longa 1 was studied. Polycyclic growth of the producer in submerged cultures was observed, with an endogenous rhythm of the periods of intense microconidia formation alternating with the phases of drastic increase in the content of producing mycelium. The highest plasminogen-like and plasminogen-activating activities (up to 1000 and 500 cond. U/mL, respectively) were found to correlate with the polycyclic growth of the producer, coinciding with the stage of microconidia germination. Enhanced secretion of proteinases with plasminogen-like and plasminogen-activating activity was found to be associated with increased specific growth rate of A. longa l.
本文研究了一种微菌Arthrobotrys longa 1生产具有纤溶酶样酶和纤溶酶原活化活性的蛋白酶。在深层培养中观察到生产者的多循环生长，其内源性节律是微分生孢子形成强烈的时期与生产菌丝体含量急剧增加的时期交替。最高的纤溶酶原样和纤溶酶原活化活性(可达1000和500天)。U/mL)与生产者的多环生长相关，与微分生孢子萌发阶段一致。具有纤溶酶原样酶和纤溶酶原活化酶活性的蛋白酶的分泌增加与长毛霉特定生长率的增加有关。
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