CXCR4-using HIV variants in a cohort of Black men who have sex with men: HIV Prevention Trials Network 061.

Q2 Medicine

HIV Clinical Trials Pub Date : 2016-07-01 Epub Date: 2016-06-14 DOI:10.1080/15284336.2016.1180771

Iris Chen, Wei Huang, Matthew B Connor, Arne Frantzell, Vanessa Cummings, Geetha G Beauchamp, Sam Griffith, Sheldon D Fields, Hyman M Scott, Steven Shoptaw, Carlos Del Rio, Manya Magnus, Sharon Mannheimer, Hong-Van Tieu, Darrell P Wheeler, Kenneth H Mayer, Beryl A Koblin, Susan H Eshleman

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引用次数: 1

Abstract

Objective: To evaluate factors associated with HIV tropism among Black men who have sex with men (MSM) in the United States enrolled in a clinical study (HIV Prevention Trials Network 061).

Methods: HIV tropism was analyzed using a phenotypic assay (Trofile assay, Monogram Biosciences). Samples were analyzed from 43 men who were HIV infected at enrollment and reported either exclusive insertive intercourse or exclusive receptive intercourse; samples were also analyzed from 20 men who were HIV uninfected at enrollment and seroconverted during the study. Clonal analysis of individual viral variants was performed for seroconverters who had dual/mixed (DM) viruses.

Results: DM viruses were detected in samples from 11 (26%) of the 43 HIV-infected men analyzed at the enrollment visit; HIV tropism did not differ between those reporting exclusive insertive vs receptive intercourse. DM viruses were also detected in five (25%) of the 20 seroconverters. DM viruses were associated with lower CD4 cell counts. Seroconverters with DM viruses had dual-tropic viruses only or mixed populations of CCR5- and dual-tropic viruses.

Conclusions: DM viruses were frequently detected among Black MSM in this study, including seroconverters. Further studies are needed to understand factors driving transmission and selection of CXCR4- and dual-tropic viruses among Black MSM.

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在与男性发生性行为的黑人男性队列中使用cxcr4的HIV变体:HIV预防试验网络061。

目的:评估参与临床研究(HIV Prevention Trials Network 061)的美国黑人男男性行为者(MSM)中与HIV倾向相关的因素。方法:采用表型分析(Trofile assay, Monogram Biosciences)分析HIV的嗜性。研究人员分析了43名在入组时感染艾滋病毒的男性的样本，他们要么报告了纯插入性行为，要么报告了纯接受性行为;还分析了20名在入组时未感染艾滋病毒并在研究期间进行血清转化的男性的样本。对携带双重/混合(DM)病毒的血清转化者进行单个病毒变异的克隆分析。结果:在入组访问时分析的43名艾滋病毒感染者中，有11名(26%)的样本检测到糖尿病病毒;HIV的倾向性在纯插入性性交和接受性性交之间没有差异。在20个服务器转换器中的5个(25%)中也检测到DM病毒。DM病毒与较低的CD4细胞计数有关。感染DM病毒的血清转化者只有双向性病毒或CCR5和双向性病毒的混合群体。结论:在本研究中，在黑人男男性行为者(包括转体者)中经常检测到糖尿病病毒。需要进一步研究CXCR4和双向性病毒在黑人男男性接触者中的传播和选择的驱动因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HIV Clinical Trials 医学-传染病学

CiteScore

1.76

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： HIV Clinical Trials is devoted exclusively to presenting information on the latest developments in HIV/AIDS clinical research. This journal enables readers to obtain the most up-to-date, innovative research from around the world.