Lung-On-A-Chip Technologies for Disease Modeling and Drug Development.

IF 2.3 Q3 ENGINEERING, BIOMEDICAL
Biomedical Engineering and Computational Biology Pub Date : 2016-04-20 eCollection Date: 2016-01-01 DOI:10.4137/BECB.S34252
Dipasri Konar, Mahesh Devarasetty, Didem V Yildiz, Anthony Atala, Sean V Murphy
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引用次数: 80

Abstract

Animal and two-dimensional cell culture models have had a profound impact on not only lung research but also medical research at large, despite inherent flaws and differences when compared with in vivo and clinical observations. Three-dimensional (3D) tissue models are a natural progression and extension of existing techniques that seek to plug the gaps and mitigate the drawbacks of two-dimensional and animal technologies. In this review, we describe the transition of historic models to contemporary 3D cell and organoid models, the varieties of current 3D cell and tissue culture modalities, the common methods for imaging these models, and finally, the applications of these models and imaging techniques to lung research.

Abstract Image

Abstract Image

用于疾病建模和药物开发的肺芯片技术。
动物和二维细胞培养模型不仅对肺部研究,而且对整个医学研究都产生了深远的影响,尽管与体内和临床观察相比存在固有的缺陷和差异。三维(3D)组织模型是现有技术的自然发展和延伸,旨在填补空白并减轻二维和动物技术的缺点。在这篇综述中,我们描述了历史模型到当代3D细胞和类器官模型的转变,当前3D细胞和组织培养模式的种类,这些模型的常见成像方法,最后,这些模型和成像技术在肺研究中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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