Role of Galectins in Allergic Disorders.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
Umut C Kucuksezer, Cevdet Ozdemir
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引用次数: 0

Abstract

Background: Allergen avoidance, pharmacotherapy; with antihistamines, anti-leukotrienes, corticosteroids and bronchodilators.as well as monoclonal antibodies; and allergen specific immunotherapy stand as confirmed approaches for the management of allergic disorders as asthma, allergic rhinitis/rhinoconjunctivitis, atopic dermatitis, food allergies and anaphylaxis. Galectins are members of animal lectin protein family, with binding specificity for β-galactoside sugars. These highly conserved proteins are known to be expressed in various effector cells of the immune system, exert immuno-regulatory activities, and enroll in tissue inflammation and regulation of immune homeostasis.

Objective: This review aims to explain the galectin family and influence of galectins in the immune mechanisms of allergic disorders.

Results: Galectins have multiple roles in innate and adaptive immunity. Intense research in the field of immunology related with galectins have given rise to several patent applications. Those, increasing in vivo efficacy of galectins for therapeutic applications, utilizing galectins for immune stimulation and prolongation of immune responses, utilization of them as disease markers are pioneers. As immune cells can be targeted by galectins, cells containing these molecules can be used for immune intervention. Regulation of cytokine productions by immune cells as IL-1β and IL-10 as well as dendritic cell functions by galectins may be efficient in limitation of some immune-mediated disorders.

Conclusion: Taken all together, better learning of galectin biology together with detailed revealing of galectin-immune system interactions have great potential for immune interventions targeting allergy-related disorders.

半凝集素在过敏性疾病中的作用。
背景:过敏原避免,药物治疗;用抗组胺药,抗白三烯,皮质类固醇和支气管扩张剂。以及单克隆抗体;过敏原特异性免疫疗法是哮喘、变应性鼻炎/鼻结膜炎、特应性皮炎、食物过敏和过敏反应等过敏性疾病的治疗方法。凝集素是动物凝集素蛋白家族的成员,具有β-半乳糖苷糖的结合特异性。已知这些高度保守的蛋白在免疫系统的各种效应细胞中表达,发挥免疫调节活性,参与组织炎症和免疫稳态调节。目的:综述凝集素家族及其在过敏性疾病免疫机制中的作用。结果:半凝集素在先天免疫和适应性免疫中具有多种作用。在免疫学领域与凝集素相关的激烈研究已经引起了一些专利申请。那些,提高体内治疗应用的功效,利用集集素进行免疫刺激和延长免疫反应,利用它们作为疾病标志物是先驱。由于免疫细胞可以被凝集素靶向,含有这些分子的细胞可以用于免疫干预。免疫细胞IL-1β和IL-10等细胞因子的产生以及凝集素对树突状细胞功能的调节可能在某些免疫介导的疾病中是有效的。结论:综上所述,更好地了解半乳糖凝集素生物学,并详细揭示半乳糖凝集素与免疫系统的相互作用,对针对过敏相关疾病的免疫干预具有很大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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