[INFLUENCE OF QUINAPRIL IN COMBINATION WITH ANGIOLINE ON THE CONNECTIVE TISSUE COMPONENTS IN THE RATS SERUM WITH EXPERIMENTAL HYPERTENSION].

Likars'ka sprava Pub Date : 2015-07-01

A A Nagornaya, S Magomedov, N A Gorchakova, I F Belenichev, I S Ghekman, T A Kuzub

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Abstract

One of the most active inhibitors angiotensin-converting enzyme is quinapril that has a high affinity for tissue ACE, improves endothelial vasodilation, has a wide therapeutic range and beneficient influence on heart rate. A new biological active compound with antioxidant action that has endothelioprotective, cardioprotective, antiischemic action is angiolin. In experimental arterial hypertension in the animals blood serum the activity of collagenase, the content of free and protein connecting fractions of hydroxyproline and indicators that reflect the metabolism of glycosaminoglycans have been increased. Angiolin increases the activity of collagenase free and protein connecting fractions of hydroxyproline comparing to control. Concentration glycosoaminoglycan (GAG) also exceeds the standard data. Quinapril has similar to angiolin action directed effect to the connective tissue components, though losing as proteinconecting of hydroxiproline action. Cooperative application quinapril with angioline most effectively influence the metabolic processes stabilization in experimental animals.

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[喹普利联合血管碱对实验性高血压大鼠血清结缔组织成分的影响]。

喹普利是血管紧张素转换酶最有效的抑制剂之一，对组织ACE具有高亲和力，可改善内皮血管舒张，治疗范围广，对心率有有益影响。血管素是一种具有抗氧化作用的新型生物活性化合物，具有保护内皮、保护心脏、抗缺血等作用。实验性动脉高血压动物血清中胶原酶活性、羟脯氨酸游离和蛋白连接部分含量及反映糖胺聚糖代谢的指标均升高。与对照组相比，血管素增加了游离胶原酶和羟脯氨酸蛋白连接部分的活性。糖氨基聚糖(GAG)浓度也超标。喹普利对结缔组织成分具有类似血管素作用的直接作用，但失去了氢希脯氨酸作用的蛋白连接作用。喹普利与血管碱联合应用对实验动物代谢过程稳定的影响最为显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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