Drug induced exfoliative dermatitis: state of the art.

Q2 Medicine

Clinical and Molecular Allergy Pub Date : 2016-08-22 eCollection Date: 2016-01-01 DOI:10.1186/s12948-016-0045-0

Mona-Rita Yacoub, Alvise Berti, Corrado Campochiaro, Enrico Tombetti, Giuseppe Alvise Ramirez, Andrea Nico, Elisabetta Di Leo, Paola Fantini, Maria Grazia Sabbadini, Eustachio Nettis, Giselda Colombo

引用次数: 20

Abstract

Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED.

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药物性剥脱性皮炎:最新进展。

药物性剥脱性皮炎(ED)是一组罕见和严重的药物超敏反应(DHR)，通常发生在药物暴露后数天至数周。多形性红斑(EM)、史蒂文斯-约翰逊综合征(SJS)和中毒性表皮坏死松解(TEN)是药物诱导ED的主要临床表现。总的来说，T细胞是这些免疫介导的药物反应的核心参与者。本文就药物性ED的发生频率、危险因素、发病机制、临床特点及治疗进行系统综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.