TOXICITY OF CHLORPYRIPHOS CONTAINING FORMULATION AND HEAVY ELEMENTS (Cd, Pb) TO CHICKEN EMBRYOS.

P Budai, A Grúz, L Várnagy, E Kormos, I M Somlyay, J Lehel, R Szabó
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Abstract

The phytotoxic effect of cadmium sulphate, lead acetate and chlorpyriphos containing insecticide Pyrinex 48 EC were investigated on chicken embryos on late developmental stage (day 19 of incubation). The eggs were injected by 0.1 ml amount of lead acetate (0.1%), of cadmium sulphate (0.01%), of Pyrinex 48 EC (chlorpyriphos, 480 g/l; 1%) and as a control 0.1 ml of bird-physiologic saline solution (0.75%). The treatments were performed on day 0 of incubation, and the embryos were examined on day 19. Number of embryonic death, developmental abnormalities and body weight of embryos were recorded on day 19. The body weight of embryos reduced significantly, the rate of embryo mortality increased, but teratogenic effect was not realised by the single treatment of lead acetate and cadmium sulphate. By the single administration of PYRINEX 48 EC the average body weight of embryos resulted in a significant decrease and the rate of embryo mortality and developmental anomalies were increased and it was found to be embryo toxic and teratogenic in the embryos. The increased embryo toxic effect can occur by the additive effect of the heavy elements (cadmium sulphate and lead acetate) and the PYRINEX 48 EC.

含制剂和重元素(Cd、Pb)毒死蜱对鸡胚的毒性研究。
研究了硫酸镉、醋酸铅和含毒死蜱杀虫剂Pyrinex 48ec对发育后期(孵育第19天)鸡胚的植物毒性作用。卵注射0.1 ml醋酸铅(0.1%)、硫酸镉(0.01%)、Pyrinex 48 EC(毒死蜱,480 g/l;1%)和0.1 ml鸟类生理盐水溶液(0.75%)作为对照。孵育第0天进行处理,第19天检查胚胎。第19天记录胚胎死亡数、发育异常数和胚胎体重。醋酸铅和硫酸镉单独处理可显著降低胚胎体重,提高胚胎死亡率,但未产生致畸作用。单次给药后,胚胎平均体重明显下降,胚胎死亡率和发育异常率增加,胚胎毒性和致畸性明显。重元素(硫酸镉和醋酸铅)与PYRINEX 48ec的加性作用可增加胚胎毒性效应。
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