PATTERN OF ANTIHYPERTENSIVE THERAPY AMONG DIABETIC HYPERTEN- SIVE PATIENTS IN ZEWDITU MEMORIAL HOSPITAL, ADDIS ABABA.

Q3 Medicine
Ethiopian Medical Journal Pub Date : 2016-04-01
Hailu Abera, Mihret Woldemichael
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引用次数: 0

Abstract

Introduction: Diabetes mellitus is becoming a common chronic disease in both developed and developing nations and is associated with significant cardiovascular disease morbidity and mortality. The presence of hypertension in patients with diabetes mellitus doubles the risk of cardiovascular disease including coronary heart disease, congestive heart failure, ischemic and hemorrhagic stroke, renalfailure and peripheral arterial disease.

Objective: The aim of this study was to assess the pattern of antihypertensive drug therapy among diabetic hypertensive patients in Zewditu Memorial Hospital Diabetic Clinic in Addis Ababa.

Methods: This is a hospital based retrospective review of medical records of 382 diabetic-hypertensive patients who visited the Zewditu Memorial Hospital Diabetic Clinic in the period between August 2014 and January 2015.

Results: The most frequently prescribed antihypertensive drug classes were angiotensin converting enzyme inhibitor in 321 (84%) followed by calcium channel blocker in 229 (60%) and beta blocker in 145 (38%) patients. Enalapril, nifedipine, atenolol, losartan and hydrochlorthiazide were the only angiotensin converting enzyme inhibitor, calcium channel blocker, beta blocker, angiotensin receptor blocker and diuretic prescribed, respectively. Enalapril was used as a monotherapy in 73 (19%) and nifedipine in 26(7%), patients. The recommended target systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg was achieved in only 57 (15%) patients while the remaining 325 (85%) did not attain the target blood pressure. Renal function was assessed in 351(92%) patients, of whom 23 (6%) had renal impairment with an estimated glomerular filtrate rate < 60 ml/min.

Conclusion: The pattern of antihypertensive drug therapy in our patients was consistent with the current treatment guidelines. However, the majority of diabetic-hypertensive patients did not reach target blood pressure.

亚的斯亚贝巴zewditu纪念医院糖尿病高血压患者的降压治疗模式。
在发达国家和发展中国家,糖尿病正成为一种常见的慢性疾病,并与心血管疾病的发病率和死亡率显著相关。糖尿病患者高血压的存在使心血管疾病的风险增加一倍,包括冠心病、充血性心力衰竭、缺血性和出血性中风、肾功能衰竭和外周动脉疾病。目的:研究亚的斯亚贝巴Zewditu纪念医院糖尿病门诊糖尿病高血压患者的降压药物治疗模式。方法:以医院为基础,回顾性分析2014年8月至2015年1月在Zewditu纪念医院糖尿病门诊就诊的382例糖尿病高血压患者的病历。结果:最常用的降压药物是血管紧张素转换酶抑制剂(321例,84%),其次是钙通道阻滞剂(229例,60%)和受体阻滞剂(145例,38%)。依那普利、硝苯地平、阿替洛尔、氯沙坦和氢氯噻嗪分别是唯一的血管紧张素转换酶抑制剂、钙通道阻滞剂、受体阻滞剂、利尿剂。73例(19%)患者使用依那普利作为单药治疗,26例(7%)患者使用硝苯地平。只有57例(15%)患者达到了推荐的目标收缩压< 140 mmHg和舒张压< 90 mmHg,而其余325例(85%)患者没有达到目标血压。351例(92%)患者进行了肾功能评估,其中23例(6%)患者肾功能受损,肾小球滤过率< 60 ml/min。结论:本组患者降压药物治疗模式与现行治疗指南一致。然而,大多数糖尿病高血压患者没有达到目标血压。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ethiopian Medical Journal
Ethiopian Medical Journal Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
发文量
0
期刊介绍: The Ethiopian Medical Journal (EMJ) is the official Journal of the Ethiopian Medical Association (EMA) and devoted to the advancement and dissemination of knowledge pertaining to the broad field of medicine in Ethiopia and other developing countries. Prospective contributors to the Journal should take note of the instructions of Manuscript preparation and submission to EMJ as outlined below.
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