The interplay of long non-coding RNAs and MYC in cancer.

IF 1.1 Q4 BIOPHYSICS
AIMS Biophysics Pub Date : 2015-01-01 Epub Date: 2015-12-01 DOI:10.3934/biophy.2015.4.794
Michael J Hamilton, Matthew D Young, Silvia Sauer, Ernest Martinez
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引用次数: 0

Abstract

Long non-coding RNAs (lncRNAs) are a class of RNA molecules that are changing how researchers view eukaryotic gene regulation. Once considered to be non-functional products of low-level aberrant transcription from non-coding regions of the genome, lncRNAs are now viewed as important epigenetic regulators and several lncRNAs have now been demonstrated to be critical players in the development and/or maintenance of cancer. Similarly, the emerging variety of interactions between lncRNAs and MYC, a well-known oncogenic transcription factor linked to most types of cancer, have caught the attention of many biomedical researchers. Investigations exploring the dynamic interactions between lncRNAs and MYC, referred to as the lncRNA-MYC network, have proven to be especially complex. Genome-wide studies have shown that MYC transcriptionally regulates many lncRNA genes. Conversely, recent reports identified lncRNAs that regulate MYC expression both at the transcriptional and post-transcriptional levels. These findings are of particular interest because they suggest roles of lncRNAs as regulators of MYC oncogenic functions and the possibility that targeting lncRNAs could represent a novel avenue to cancer treatment. Here, we briefly review the current understanding of how lncRNAs regulate chromatin structure and gene transcription, and then focus on the new developments in the emerging field exploring the lncRNA-MYC network in cancer.

Abstract Image

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癌症中长非编码 RNA 与 MYC 的相互作用。
长非编码 RNA(lncRNA)是一类 RNA 分子,它正在改变研究人员对真核生物基因调控的看法。lncRNA曾被认为是基因组非编码区低水平异常转录的无功能产物,现在则被视为重要的表观遗传调控因子,有几种lncRNA已被证明是癌症发生和/或维持的关键因素。同样,lncRNA 与 MYC(一种众所周知的与大多数癌症类型有关的致癌转录因子)之间新出现的各种相互作用也引起了许多生物医学研究人员的注意。事实证明,探索 lncRNA 与 MYC(被称为 lncRNA-MYC 网络)之间动态相互作用的研究尤其复杂。全基因组研究表明,MYC转录调控许多lncRNA基因。相反,最近的报告发现了在转录和转录后水平上调控 MYC 表达的 lncRNA。这些发现特别令人感兴趣,因为它们表明了 lncRNAs 作为 MYC 致癌功能调节因子的作用,以及靶向 lncRNAs 可能代表一种新的癌症治疗途径。在此,我们简要回顾了目前对lncRNA如何调控染色质结构和基因转录的理解,然后重点介绍了探索癌症中lncRNA-MYC网络这一新兴领域的新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIMS Biophysics
AIMS Biophysics BIOPHYSICS-
CiteScore
2.40
自引率
20.00%
发文量
16
审稿时长
8 weeks
期刊介绍: AIMS Biophysics is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers in the field of biophysics. We publish the following article types: original research articles, reviews, editorials, letters, and conference reports. AIMS Biophysics welcomes, but not limited to, the papers from the following topics: · Structural biology · Biophysical technology · Bioenergetics · Membrane biophysics · Cellular Biophysics · Electrophysiology · Neuro-Biophysics · Biomechanics · Systems biology
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