Rich club network analysis shows distinct patterns of disruption in frontotemporal dementia and Alzheimer's disease.

Mathematics and visualization Pub Date : 2014-01-01 DOI:10.1007/978-3-319-11182-7_2

Madelaine Daianu, Neda Jahanshad, Julio E Villalon-Reina, Mario F Mendez, George Bartzokis, Elvira E Jimenez, Aditi Joshi, Joseph Barsuglia, Paul M Thompson

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引用次数: 10

Abstract

Diffusion imaging and brain connectivity analyses can reveal the underlying organizational patterns of the human brain, described as complex networks of densely interlinked regions. Here, we analyzed 1.5-Tesla whole-brain diffusion-weighted images from 64 participants - 15 patients with behavioral variant frontotemporal (bvFTD) dementia, 19 with early-onset Alzheimer's disease (EOAD), and 30 healthy elderly controls. Based on whole-brain tractography, we reconstructed structural brain connectivity networks to map connections between cortical regions. We examined how bvFTD and EOAD disrupt the weighted 'rich club' - a network property where high-degree network nodes are more interconnected than expected by chance. bvFTD disrupts both the nodal and global organization of the network in both low- and high-degree regions of the brain. EOAD targets the global connectivity of the brain, mainly affecting the fiber density of high-degree (highly connected) regions that form the rich club network. These rich club analyses suggest distinct patterns of disruptions among different forms of dementia.

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丰富的俱乐部网络分析显示，额颞叶痴呆和阿尔茨海默病的破坏模式不同。

扩散成像和大脑连接分析可以揭示人类大脑的潜在组织模式，被描述为密集互连区域的复杂网络。在这里，我们分析了64名参与者的1.5特斯拉全脑扩散加权图像——15名行为变异额颞叶痴呆患者、19名早发性阿尔茨海默病患者和30名健康老年对照。在全脑束成像的基础上，我们重建了大脑结构连接网络，以绘制皮层区域之间的连接。我们研究了bvFTD和EOAD是如何破坏加权的“富裕俱乐部”的——这是一种网络特性，其中高度网络节点的互联程度比预期的要高。bvFTD破坏了大脑低度和高度区域网络的节点和全局组织。EOAD的目标是大脑的全球连通性，主要影响形成丰富俱乐部网络的高度（高度连通）区域的纤维密度。这些丰富的俱乐部分析表明，不同形式的痴呆症之间存在不同的干扰模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mathematics and visualization

CiteScore

1.40

自引率

0.00%

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