Uric Acid Levels in Normotensive Children of Hypertensive Parents.

International Journal of Chronic Diseases Pub Date : 2015-01-01 Epub Date: 2015-08-24 DOI:10.1155/2015/747082
Ali Yildirim, Fatma Keles, Pelin Kosger, Gokmen Ozdemir, Birsen Ucar, Zubeyir Kilic
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引用次数: 3

Abstract

This study evaluated uric acid concentrations in normotensive children of parents with hypertension. Eighty normotensive children from families with and without a history of essential hypertension were included. Concentrations of lipid parameters and uric acid were compared. Demographic and anthropometric characteristics were similar in the groups. Systolic and diastolic blood pressure were higher in the normotensive children of parents with hypertension without statistically significant difference (P > 0.05). Uric acid concentrations were higher in the normotensive children of parents with hypertension (4.61 versus 3.57 mg/dL, P < 0.01). Total cholesterol and triglyceride concentrations were similar in the two groups. Systolic and diastolic blood pressure were significantly higher in control children aged >10 years (P < 0.01). Uric acid levels were significantly higher in all children with more pronounced difference after age 10 of years (P < 0.001). Positive correlations were found between the level of serum uric acid and age, body weight, body mass index, and systolic and diastolic blood pressure in the normotensive children of parents. The higher uric acid levels in the normotensive children of hypertensive parents suggest that uric acid may be a predeterminant of hypertension. Monitoring of uric acid levels in these children may allow for prevention or earlier treatment of future hypertension.

高血压父母的正常儿童的尿酸水平
本研究评估父母有高血压的正常儿童的尿酸浓度。80名来自有或无原发性高血压病史家庭的正常儿童被纳入研究。比较血脂参数和尿酸浓度。两组的人口统计学和人体测量学特征相似。高血压家长血压正常的儿童收缩压、舒张压升高,差异无统计学意义(P > 0.05)。血压正常且父母有高血压的儿童尿酸浓度较高(4.61 vs 3.57 mg/dL, P < 0.01)。两组的总胆固醇和甘油三酯浓度相似。对照组>10岁患儿的收缩压和舒张压均显著升高(P < 0.01)。所有儿童的尿酸水平均显著升高,10岁后差异更明显(P < 0.001)。在父母血压正常的儿童中,血清尿酸水平与年龄、体重、体重指数、收缩压和舒张压呈正相关。高血压父母的正常儿童的高尿酸水平提示尿酸可能是高血压的一个先兆因素。监测这些儿童的尿酸水平可能有助于预防或早期治疗未来的高血压。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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