Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats.

Q1 Pharmacology, Toxicology and Pharmaceutics

Advances in Pharmacological Sciences Pub Date : 2015-01-01 Epub Date: 2015-09-03 DOI:10.1155/2015/801053

Aghdas Dehghani, Shadan Saberi, Mehdi Nematbakhsh

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引用次数: 12

Abstract

Background. The accompanied role of Mas receptor (MasR), bradykinin (BK), and female sex hormone on renal blood flow (RBF) response to angiotensin 1-7 is not well defined. We investigated the role of MasR antagonist (A779) and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats. Methods. Ovariectomized Wistar rats received estradiol (OVE) or vehicle (OV) for two weeks. Catheterized animals were subjected to BK and A799 infusion and mean arterial pressure (MAP), RBF, and renal vascular resistance (RVR) responses to Ang 1-7 (0, 100, and 300 ng kg(-1) min(-1)) were determined. Results. Percentage change of RBF (%RBF) in response to Ang1-7 infusion increased in a dose-dependent manner. In the presence of BK, when MasR was not blocked, %RBF response to Ang 1-7 in OVE group was greater than OV group significantly (P < 0.05). Infusion of 300 ng kg(-1) min(-1) Ang 1-7 increased RBF by 6.9 ± 1.9% in OVE group versus 0.9 ± 1.8% in OV group. However when MasR was blocked, %RBF response to Ang 1-7 in OV group was greater than OVE group insignificantly. Conclusion. Coadministration of BK and A779 compared to BK alone increased RBF response to Ang 1-7 in vehicle treated rats. Such observation was not seen in estradiol treated rats.

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Mas受体拮抗剂A799在去卵巢雌二醇治疗大鼠缓激肽后肾血流对Ang 1-7的反应中的作用。

背景。Mas受体(MasR)、缓激素(BK)和女性性激素对肾血流(RBF)对血管紧张素1-7的反应的伴随作用尚未明确。我们研究了MasR拮抗剂(A779)和BK对去卵巢雌二醇处理大鼠RBF对Ang 1-7输注反应的作用。方法。切除卵巢的Wistar大鼠接受雌二醇(OVE)或对照物(OV)治疗两周。置管动物接受BK和A799输注，测定平均动脉压(MAP)、RBF和肾血管阻力(RVR)对Ang 1-7(0、100和300 ng kg(-1) min(-1))的反应。结果。灌注Ang1-7后RBF变化百分比(%RBF)呈剂量依赖性增加。在BK存在的情况下，在未阻断MasR的情况下，OVE组对Ang 1-7的%RBF应答显著大于OV组(P < 0.05)。OVE组注射300 ng kg(-1) min(-1) Ang 1-7使RBF增加6.9±1.9%，OV组增加0.9±1.8%。而阻断MasR后，OV组对Ang 1-7的%RBF应答显著高于OVE组。结论。与单独给药BK相比，BK和A779联合给药增加了小鼠对Ang 1-7的RBF反应。雌二醇处理的大鼠未见此现象。

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来源期刊

Advances in Pharmacological Sciences PHARMACOLOGY & PHARMACY-

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Advances in Pharmacological and Pharmaceutical Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery. Topics covered by the journal include, but are not limited to: -Biochemical pharmacology, drug mechanism of action, pharmacodynamics, pharmacogenetics, pharmacokinetics, and toxicology. -The design and preparation of new drugs, and their safety and efficacy in humans, including descriptions of drug dosage forms. -All areas of medicinal chemistry, such as drug discovery, design and synthesis. -Basic biology of drug and gene delivery through to application and development of these principles, through therapeutic delivery and targeting. Areas covered include bioavailability, controlled release, microcapsules, novel drug delivery systems, personalized drug delivery, and techniques for passing biological barriers.