BF3·Et2O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization.

Q1 Pharmacology, Toxicology and Pharmaceutics

Advances in Pharmacological Sciences Pub Date : 2015-01-01 Epub Date: 2015-09-01 DOI:10.1155/2015/527159

Ambika Srivastava, Pooja Singh, Rajesh Kumar

引用次数: 0

Abstract

We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF3·Et2O catalyzed reaction was found to be selective for product formation while anhydrous AlCl3, FeCl3, and SnCl4 catalyzed ones were nonselective.

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BF3-Et2O 催化的 4-芳基-3-苯基苯并吡喃酮、Pro-SERMs 及其表征。

我们合成了新型 4-(4-羟基-苄基)-3-苯基-2-苯并吡喃酮，它是一种 SERM 的前体，合成步骤少，收率高。合成方法有两种。发现无水 BF3-Et2O 催化的反应对产物的形成具有选择性，而无水 AlCl3、FeCl3 和 SnCl4 催化的反应则没有选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Pharmacological Sciences PHARMACOLOGY & PHARMACY-

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Advances in Pharmacological and Pharmaceutical Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery. Topics covered by the journal include, but are not limited to: -Biochemical pharmacology, drug mechanism of action, pharmacodynamics, pharmacogenetics, pharmacokinetics, and toxicology. -The design and preparation of new drugs, and their safety and efficacy in humans, including descriptions of drug dosage forms. -All areas of medicinal chemistry, such as drug discovery, design and synthesis. -Basic biology of drug and gene delivery through to application and development of these principles, through therapeutic delivery and targeting. Areas covered include bioavailability, controlled release, microcapsules, novel drug delivery systems, personalized drug delivery, and techniques for passing biological barriers.