{"title":"[A Case of Corneal Injury due to Herbicide Containing Paraquat: Effectiveness of 2% Rebamipide Eye Drops].","authors":"Makoto Uno","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Herbicides containing paraquat are widely used and have occasionally been causing ocular damage. The initial ocular injury caused by paraquat tends to worsen within a few days to 1 week. The toxicity of paraquat is based on the oxidative stress induced by reactive oxygen species.</p><p><strong>Case: </strong>An 82-year-old woman who had been exposed to herbicide containing paraquat in her left eye presented at Koumeikan Eye Clinic 2 days after the incident. Moderate corneal erosion was diagnosed and treated with ordinary medication, but the corneal lesion worsened. After administration of topical 2% rebamipide eye drops, the corneal lesion resolved rapidly.</p><p><strong>Conclusion: </strong>Because of its role as a radical scavenger, rebamipide has great potential for treatment of corneal injuries caused by herbicides such as paraquat.</p>","PeriodicalId":19670,"journal":{"name":"Nippon Ganka Gakkai zasshi","volume":"119 8","pages":"521-6"},"PeriodicalIF":0.0000,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nippon Ganka Gakkai zasshi","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Herbicides containing paraquat are widely used and have occasionally been causing ocular damage. The initial ocular injury caused by paraquat tends to worsen within a few days to 1 week. The toxicity of paraquat is based on the oxidative stress induced by reactive oxygen species.
Case: An 82-year-old woman who had been exposed to herbicide containing paraquat in her left eye presented at Koumeikan Eye Clinic 2 days after the incident. Moderate corneal erosion was diagnosed and treated with ordinary medication, but the corneal lesion worsened. After administration of topical 2% rebamipide eye drops, the corneal lesion resolved rapidly.
Conclusion: Because of its role as a radical scavenger, rebamipide has great potential for treatment of corneal injuries caused by herbicides such as paraquat.
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