The utility of transposon mutagenesis for cancer studies in the era of genome editing.

IF 12.3 1区生物学 Q1 Agricultural and Biological Sciences

Genome Biology Pub Date : 2015-10-19 DOI:10.1186/s13059-015-0794-y

Gina M DeNicola, Florian A Karreth, David J Adams, Chi C Wong

引用次数: 2

Abstract

The use of transposons as insertional mutagens to identify cancer genes in mice has generated a wealth of information over the past decade. Here, we discuss recent major advances in transposon-mediated insertional mutagenesis screens and compare this technology with other screening strategies.

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在基因组编辑时代，转座子突变在癌症研究中的应用。

在过去的十年中，利用转座子作为插入诱变剂来识别小鼠的癌症基因已经产生了丰富的信息。在这里，我们讨论了最近在转座子介导的插入突变筛选方面的主要进展，并将该技术与其他筛选策略进行了比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genome Biology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY

CiteScore

25.50

自引率

3.30%

发文量

审稿时长

14 weeks

期刊介绍： Genome Biology is a leading research journal that focuses on the study of biology and biomedicine from a genomic and post-genomic standpoint. The journal consistently publishes outstanding research across various areas within these fields. With an impressive impact factor of 12.3 (2022), Genome Biology has earned its place as the 3rd highest-ranked research journal in the Genetics and Heredity category, according to Thomson Reuters. Additionally, it is ranked 2nd among research journals in the Biotechnology and Applied Microbiology category. It is important to note that Genome Biology is the top-ranking open access journal in this category. In summary, Genome Biology sets a high standard for scientific publications in the field, showcasing cutting-edge research and earning recognition among its peers.