The Triglyceride Paradox in Stroke Survivors: A Prospective Study.

Neuroscience journal Pub Date : 2013-01-01 Epub Date: 2013-02-25 DOI:10.1155/2013/870608

Minal Jain, Anunaya Jain, Neeraja Yerragondu, Robert D Brown, Alejandro Rabinstein, Babak S Jahromi, Lekshmi Vaidyanathan, Brian Blyth, Latha Ganti Stead

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引用次数: 35

Abstract

Objective. The purpose of our study was to understand the association between serum triglycerides and outcomes in acute ischemic stroke (AIS) patients. Methods. A cohort of all adult patients presenting to the Emergency Department (ED) with an AIS from March 2004 to December 2005 were selected. The lipid profile levels were measured within 24 hours of stroke onset. Demographics, admission stroke severity (NIHSS), functional outcome at discharge (modified Rankin Scale (mRS)), and mortality at 3 months were recorded. Results. The final cohort consisted of 334 subjects. A lower level of triglycerides at presentation was found to be significantly associated with worse National Institutes of Health Stroke Scale (NIHSS) (P = 0.004), worse mRS (P = 0.02), and death at 3 months (P = 0.0035). After adjusting for age and gender and NIHSS, the association between triglyceride and mortality at 3 months was not significant (P = 0.26). Conclusion. Lower triglyceride levels seem to be associated with a worse prognosis in AIS.

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中风幸存者的甘油三酯悖论:一项前瞻性研究。

目标。本研究的目的是了解急性缺血性卒中(AIS)患者血清甘油三酯与预后之间的关系。方法。本研究选取了2004年3月至2005年12月在急诊科(ED)就诊的所有患有AIS的成年患者。在中风发作后24小时内测量血脂水平。记录人口统计学、入院时脑卒中严重程度(NIHSS)、出院时功能结局(改良Rankin量表(mRS))和3个月死亡率。结果。最后的队列包括334名受试者。研究发现，发病时较低的甘油三酯水平与较差的美国国立卫生研究院卒中量表(NIHSS) (P = 0.004)、较差的mRS (P = 0.02)和3个月时的死亡(P = 0.0035)显著相关。在调整年龄、性别和NIHSS后，甘油三酯与3个月死亡率之间的相关性无统计学意义(P = 0.26)。结论。较低的甘油三酯水平似乎与AIS患者较差的预后有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neuroscience journal

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