An Atypical Presentation with Diagnostic Challenge of a Large Cell Neuroendocrine Cancer of Lung: A Case Report and Review of the Literature.

Lung cancer international Pub Date : 2011-01-01 Epub Date: 2011-06-14 DOI:10.4061/2011/912098
Pavan Kumar Bhamidipati, Amanda Ribbeck, Goldees Liaghati-Nasseri, Ramesh Kumar, Babu Paidipaty B, John Bartnik
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引用次数: 5

Abstract

Large-cell neuroendocrine carcinomas (LCNECs) are relatively rare and aggressive neoplasms of the lung with very poor prognosis. Even though they are included in the classification of nonsmall cell carcinomas, they have a biological behaviour and physiological response to treatment more like small cell carcinomas of lung. We report an atypical case presentation of LCNEC in a 51-year-old gentleman who presented with diffuse metastases to the thoracic and lumbar spine, brain, and liver, posing a diagnostic challenge. The primary small central lung tumor was in close proximity to major vessels, rendering a biopsy of the primary cancer challenging and nearly impossible. The final diagnosis was established through immunohistochemistry staining and examination of liver biopsy from a metastatic lesion. We also included a review of the current literature pertinent to LCNEC, as well as the important role of tumor markers plus immunohistochemistry profiles in determining the origin of unknown primary tumors in such difficult patient presentations.

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肺大细胞神经内分泌癌的非典型表现及诊断挑战:1例报告及文献复习。
大细胞神经内分泌癌(lcnec)是一种相对罕见的侵袭性肺肿瘤,预后非常差。尽管它们被纳入非小细胞癌的分类,但它们对治疗的生物学行为和生理反应更像肺小细胞癌。我们报告一例51岁男性LCNEC的非典型病例,其表现为弥漫性转移至胸椎、腰椎、脑和肝脏,这给诊断带来了挑战。原发性小中央肺肿瘤靠近主要血管,使得原发性肿瘤活检具有挑战性,几乎不可能。最终诊断是通过免疫组织化学染色和肝活检检查转移灶。我们还回顾了当前与LCNEC相关的文献,以及肿瘤标志物和免疫组织化学谱在确定此类困难患者的未知原发肿瘤起源方面的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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